核酸自由基的反应性。

4区 化学 Q3 Chemistry
Marc M Greenberg
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引用次数: 19

摘要

核酸氧化在疾病的病因、治疗以及衰老过程中起着至关重要的作用。氧化核酸的试剂也是生物聚合物结构和折叠的有用探针。辐射科学家利用各种技术对我们对核酸氧化的理解做出了巨大贡献。近二十年来,有机化学家运用合成化学和机械化学的工具,独立生成和研究电离辐射和其他核酸损伤剂产生的反应性中间体。这种方法有助于解决机制上的争议,并导致新的反应过程的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reactivity of Nucleic Acid Radicals.

Reactivity of Nucleic Acid Radicals.

Reactivity of Nucleic Acid Radicals.

Reactivity of Nucleic Acid Radicals.

Nucleic acid oxidation plays a vital role in the etiology and treatment of diseases, as well as aging. Reagents that oxidize nucleic acids are also useful probes of the biopolymers' structure and folding. Radiation scientists have contributed greatly to our understanding of nucleic acid oxidation using a variety of techniques. During the past two decades organic chemists have applied the tools of synthetic and mechanistic chemistry to independently generate and study the reactive intermediates produced by ionizing radiation and other nucleic acid damaging agents. This approach has facilitated resolving mechanistic controversies and lead to the discovery of new reactive processes.

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CiteScore
2.40
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