MicroRNA 21在肥胖糖尿病患者脂肪组织中表达上调。

Q3 Medicine

Nutrition and Healthy Aging Pub Date : 2017-03-31 DOI:10.3233/NHA-160020

Valeria Guglielmi, Monica D'Adamo, Rossella Menghini, Marina Cardellini, Paolo Gentileschi, Massimo Federici, Paolo Sbraccia

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引用次数: 30

摘要

我们研究了16名接受减肥手术的肥胖患者大网膜(OAT)和皮下脂肪组织(SAT)中miR21的表达。根据是否存在2型糖尿病(T2D)，将患者分为年龄和bmi匹配的两组。miR21在OAT和SAT中的表达没有差异。然而，在T2D患者的脂肪组织中，miR21的表达高出两倍。因此，在非糖尿病超重受试者的脂肪细胞原代培养中，暴露于高糖和胰岛素24小时后，miR21表达增加。总之，miR21似乎与从肥胖到t2dm的病理生理进展中的胰岛素抵抗恶化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects.

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MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects.

We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.

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来源期刊

Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.