比较阴道内米索前列醇和阴道内吉美前列素两种方案用于中期妊娠终止:一项随机对照试验。

Q Medicine
Daniel Seow Choon Koh, Esther Pei Jing Ang, Jurja Chua Coyuco, Hua Zhen Teo, Xiaoling Huang, Xing Wei, Mor Jack Ng, Serene Liqing Lim, Kok Hian Tan
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引用次数: 3

摘要

目的:比较阴道内注射米索前列醇200µg、400µg和吉美前列素用于中期妊娠终止(TOP)的疗效和安全性。方法:一项三手随机对照试验(临床试验证书1100015),116名妊娠中期TOP的妇女每隔4小时给予阴道内米索前列醇200µg (n=37),米索前列醇400µg (n=40)或吉美前列醇1mg (n=39),直到流产,最多5次剂量。结果:米索前列醇400µg组流产成功率(92.5%)高于米索前列醇200µg组(70.3%);P =0.017)和吉美前列素1 mg (74.4%;P =0.037)。米索前列醇200µg与吉美前列素流产率无显著差异。米索前列醇400µg组与米索前列醇200µg组相比,发热发生率最高(70.0%);页= 0.041)。与米索前列醇400µg组相比,吉美前列素组腹泻发生率最高(38.5%)。P =0.004),米索前列醇200µg (8.1%;p = 0.003)。结论:阴道内注射米索前列醇400µg,间隔4小时是最有效的治疗方案,但与高发发热相关。米索前列醇200µg显示出与吉美前列素相似的效果,并且腹泻发生率更低。考虑到成本、储存要求和较低的疗效,吉美前列素不应作为一线药物治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing two regimens of intravaginal misoprostol with intravaginal gemeprost for second-trimester pregnancy termination: a randomised controlled trial.

Aim: To compare the efficacy and safety of intravaginal misoprostol 200 µg, 400 µg and gemeprost regimens for second-trimester termination of pregnancy (TOP).

Methods: A three- armed randomi sed controlled trial (Clinical Trial Certificate 1100015) where 116 women undergoing second-trimester TOP were given intravaginal misoprostol 200 µ g (n=37), misoprostol 400 µg (n=40) or gemeprost 1 mg (n=39) at 4- hour intervals until abortion occurred with a maximum of five doses.

Results: The misoprostol 400 µg group had the highest incidence of successful abortions (92.5%) compared to the misoprostol 200 µg (70.3%; p=0.017) and gemeprost 1 mg (74.4%; p=0.037) within 48 hours. There was no significant difference in abortion rate between misoprostol 200 µg and gemeprost. The misoprostol 400 µg group had the highest incidence of fever (70.0%) compared to misoprostol 200 µg (24.3%; p<0.001) and gemeprost 1 mg (46.2%; p=0.041). The gemeprost group had the highest incidence of diarrhoea (38.5%) compared to misoprostol 400 µg (10.0%; p=0.004) and misoprostol 200 µg (8.1%; p=0.003) groups.

Conclusions: Intravaginal misoprostol 400 µ g at 4- hour intervals was the most effective regimen but was associated with a high incidence of fever. Misoprostol 200 µg demonstrated similar effectiveness as gemeprost and had lower incidence of diarrhoea. Gemeprost should not be first line for medical therapy given the cost, storage requirements and lower efficacy.

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CiteScore
0.84
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期刊介绍: The trading of Professional, Managerial & Healthcare Publications Ltd has been transferred to its parent company, Keyways Publishing Ltd.
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