Hsiao-Mei Liao , Chien-Chung Chao , Haiyan Lei , Bingjie Li , Shien Tsai , Guo-Chiuan Hung , Wei-Mei Ching , Shyh-Ching Lo
{"title":"不同抗生素敏感性恙虫东方体的种内比较基因组学研究","authors":"Hsiao-Mei Liao , Chien-Chung Chao , Haiyan Lei , Bingjie Li , Shien Tsai , Guo-Chiuan Hung , Wei-Mei Ching , Shyh-Ching Lo","doi":"10.1016/j.gdata.2017.03.012","DOIUrl":null,"url":null,"abstract":"<div><p>We recently reported the genome of <em>Orientia tsutsugamushi</em> (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, <span>https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2</span><svg><path></path></svg>) with ><!--> <!-->2<!--> <!-->Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession #: NZ_LYMT00000000.1, <span>https://www.ncbi.nlm.nih.gov/nuccore/1035784408</span><svg><path></path></svg>) and AFSC7 (GenBank Accession #: NZ_LYMB00000000.1, <span>https://www.ncbi.nlm.nih.gov/nuccore/1035854767</span><svg><path></path></svg>) were more resistant to antibiotics than strain Karp, we conducted comparative analysis of the three draft genomes annotated by RAST server aimed to identify possible genetic bases of difference in microbial antibiotic sensitivity. Intraspecies comparative genomics analysis of the three OT strains revealed that two ORFs encoding hypothetical proteins in both strains AFSC4 and AFSC7 are absent in strain Karp.</p></div>","PeriodicalId":56340,"journal":{"name":"Genomics Data","volume":"12 ","pages":"Pages 84-88"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gdata.2017.03.012","citationCount":"7","resultStr":"{\"title\":\"Intraspecies comparative genomics of three strains of Orientia tsutsugamushi with different antibiotic sensitivity\",\"authors\":\"Hsiao-Mei Liao , Chien-Chung Chao , Haiyan Lei , Bingjie Li , Shien Tsai , Guo-Chiuan Hung , Wei-Mei Ching , Shyh-Ching Lo\",\"doi\":\"10.1016/j.gdata.2017.03.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We recently reported the genome of <em>Orientia tsutsugamushi</em> (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, <span>https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2</span><svg><path></path></svg>) with ><!--> <!-->2<!--> <!-->Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession #: NZ_LYMT00000000.1, <span>https://www.ncbi.nlm.nih.gov/nuccore/1035784408</span><svg><path></path></svg>) and AFSC7 (GenBank Accession #: NZ_LYMB00000000.1, <span>https://www.ncbi.nlm.nih.gov/nuccore/1035854767</span><svg><path></path></svg>) were more resistant to antibiotics than strain Karp, we conducted comparative analysis of the three draft genomes annotated by RAST server aimed to identify possible genetic bases of difference in microbial antibiotic sensitivity. Intraspecies comparative genomics analysis of the three OT strains revealed that two ORFs encoding hypothetical proteins in both strains AFSC4 and AFSC7 are absent in strain Karp.</p></div>\",\"PeriodicalId\":56340,\"journal\":{\"name\":\"Genomics Data\",\"volume\":\"12 \",\"pages\":\"Pages 84-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.gdata.2017.03.012\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genomics Data\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213596017300181\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genomics Data","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213596017300181","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Intraspecies comparative genomics of three strains of Orientia tsutsugamushi with different antibiotic sensitivity
We recently reported the genome of Orientia tsutsugamushi (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2) with > 2 Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession #: NZ_LYMT00000000.1, https://www.ncbi.nlm.nih.gov/nuccore/1035784408) and AFSC7 (GenBank Accession #: NZ_LYMB00000000.1, https://www.ncbi.nlm.nih.gov/nuccore/1035854767) were more resistant to antibiotics than strain Karp, we conducted comparative analysis of the three draft genomes annotated by RAST server aimed to identify possible genetic bases of difference in microbial antibiotic sensitivity. Intraspecies comparative genomics analysis of the three OT strains revealed that two ORFs encoding hypothetical proteins in both strains AFSC4 and AFSC7 are absent in strain Karp.
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