CRKL在乳腺癌转移中的作用:来自系统生物学的见解。

Systems and Synthetic Biology Pub Date : 2015-12-01 Epub Date: 2015-09-10 DOI:10.1007/s11693-015-9180-z
Abderrahim Chafik
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引用次数: 5

摘要

乳腺癌转移是一个复杂的过程,涉及多种细胞途径,但对其了解甚少。它是乳腺癌死亡的主要原因。最近,microRNAs (miRNAs),一种通过转录后调控基因表达的小非编码rna,被证明参与了乳腺癌的转移。特别是在最近的一项研究中发现,miR-429可能在抑制乳腺癌细胞的迁移和侵袭中起作用。其靶基因CRKL已被确定为潜在的候选基因。在本文中,我们利用系统生物学工具证明了CRKL参与ERK1/2信号通路的正向调节,并通过前馈回路的拓扑推广参与LYN的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of CRKL in breast cancer metastasis: insights from systems biology.

The role of CRKL in breast cancer metastasis: insights from systems biology.

The role of CRKL in breast cancer metastasis: insights from systems biology.

The role of CRKL in breast cancer metastasis: insights from systems biology.

Breast cancer metastasis is a complex and still weakly understood process that involves diverse cellular pathways. It accounts for the majority of deaths from breast cancer. Recently, microRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, have been shown to be involved in breast cancer metastasis. In particular, in a recent work it has been found that miR-429 may have a role in the inhibition of migration and invasion of breast cancer cells. Its target gene CRKL has been identified as a potential candidate. In this paper, by using systems biology tools we have shown that CRKL is involved in positive regulation of ERK1/2 signaling pathway and contribute to the regulation of LYN through a topological generalization of feed forward loop.

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