Mariola Brycht, Agnieszka Nosal-Wiercińska, Karolina Sipa, Konrad Rudnicki, Sławomira Skrzypek
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In addition, a relevance of the developed SWAdSV method was successfully verified by the quantitative analysis of closantel in the commercial formulation Closamectin Pour-On with satisfactory results (RSD = 5.8%, recovery = 101.8%). The results showed that the developed procedure can be adequate for screening purposes. Also, the electrochemical behavior of closantel was characterized by cyclic voltammetry, and it was found that closantel exhibited a quasi-reversible behavior with cathodic peak on the forward scan at ca. -1.4 V and anodic peak on the reverse scan at ca. -1.35 V vs. Ag/AgCl in B-R buffer, pH 7.0. As the obtained results showed that the electrode mechanism of closantel is controlled by the adsorption, the effect of adsorption was studied using the electrochemical impedance spectroscopy technique.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":18766,"journal":{"name":"Monatshefte Fur Chemie","volume":"148 3","pages":"463-472"},"PeriodicalIF":1.7000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00706-016-1862-z","citationCount":"11","resultStr":"{\"title\":\"Electrochemical determination of closantel in the commercial formulation by square-wave adsorptive stripping voltammetry.\",\"authors\":\"Mariola Brycht, Agnieszka Nosal-Wiercińska, Karolina Sipa, Konrad Rudnicki, Sławomira Skrzypek\",\"doi\":\"10.1007/s00706-016-1862-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal conditions, the SWAdSV response of Hg(Ag)FE for determining closantel was linear over two concentration ranges of 5.0 × 10<sup>-8</sup> to 2.0 × 10<sup>-7</sup> mol dm<sup>-3</sup> and 2.0 × 10<sup>-7</sup> to 1.2 × 10<sup>-6</sup> mol dm<sup>-3</sup> with a detection limit of 1.1 × 10<sup>-8</sup> mol dm<sup>-3</sup>. In addition, a relevance of the developed SWAdSV method was successfully verified by the quantitative analysis of closantel in the commercial formulation Closamectin Pour-On with satisfactory results (RSD = 5.8%, recovery = 101.8%). The results showed that the developed procedure can be adequate for screening purposes. Also, the electrochemical behavior of closantel was characterized by cyclic voltammetry, and it was found that closantel exhibited a quasi-reversible behavior with cathodic peak on the forward scan at ca. -1.4 V and anodic peak on the reverse scan at ca. -1.35 V vs. Ag/AgCl in B-R buffer, pH 7.0. 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Electrochemical determination of closantel in the commercial formulation by square-wave adsorptive stripping voltammetry.
Abstract: In this paper, the square-wave adsorptive stripping voltammetric (SWAdSV) determination of the veterinary drug closantel using a renewable silver amalgam film electrode (Hg(Ag)FE) is presented. As observed in SWAdSV, closantel provided one well-shaped reduction peak suitable for analytical purposes at potential ca. -1.4 V in the Britton-Robinson (B-R) buffer at pH 7.0. At optimal conditions, the SWAdSV response of Hg(Ag)FE for determining closantel was linear over two concentration ranges of 5.0 × 10-8 to 2.0 × 10-7 mol dm-3 and 2.0 × 10-7 to 1.2 × 10-6 mol dm-3 with a detection limit of 1.1 × 10-8 mol dm-3. In addition, a relevance of the developed SWAdSV method was successfully verified by the quantitative analysis of closantel in the commercial formulation Closamectin Pour-On with satisfactory results (RSD = 5.8%, recovery = 101.8%). The results showed that the developed procedure can be adequate for screening purposes. Also, the electrochemical behavior of closantel was characterized by cyclic voltammetry, and it was found that closantel exhibited a quasi-reversible behavior with cathodic peak on the forward scan at ca. -1.4 V and anodic peak on the reverse scan at ca. -1.35 V vs. Ag/AgCl in B-R buffer, pH 7.0. As the obtained results showed that the electrode mechanism of closantel is controlled by the adsorption, the effect of adsorption was studied using the electrochemical impedance spectroscopy technique.
期刊介绍：
"Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.
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