肢体预模式的二域假设及其与先天性肢体异常的关系。

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2017-07-01 Epub Date: 2017-03-20 DOI:10.1002/wdev.270

Hirotaka Tao, Yasuhiko Kawakami, Chi-Chung Hui, Sevan Hopyan

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引用次数: 9

摘要

对导致人类肢体异常的突变的功能注释是通过基础发育研究实现的。在这项研究中，我们关注肢体发育的预模式阶段，并讨论了一个最近的模型，该模型提出早期肢体芽的前后域产生未来骨骼的两半。通过比较人类与模式生物的表型，我们评估这种预模式概念是否有助于注释人类疾病等位基因。中国生物医学工程学报，2017,26(6):779 - 779。doi: 10.1002 / wdev.270有关与本文相关的更多资源，请访问WIREs网站。

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The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.

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The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.

Functional annotation of mutations that cause human limb anomalies is enabled by basic developmental studies. In this study, we focus on the prepatterning stage of limb development and discuss a recent model that proposes anterior and posterior domains of the early limb bud generate two halves of the future skeleton. By comparing phenotypes in humans with those in model organisms, we evaluate whether this prepatterning concept helps to annotate human disease alleles. WIREs Dev Biol 2017, 6:e270. doi: 10.1002/wdev.270 For further resources related to this article, please visit the WIREs website.

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来源期刊

Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.