{"title":"小体积酶反应的微观自组织","authors":"A. Mikhailov, B. Hess","doi":"10.1021/jp9616627","DOIUrl":null,"url":null,"abstract":"<p >Using an enzymic reaction with allosteric product activation as example, we show that allosterically regulated reactions in small volumes may develop strong microscopic correlations between individual molecular reaction events. Such correlations lead to coherent synchronous activity of the enzymic molecular population which is revealed in frequent periodic spiking of the reaction. </p>","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"100 49","pages":"19059–19065"},"PeriodicalIF":2.7810,"publicationDate":"1996-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1021/jp9616627","citationCount":"28","resultStr":"{\"title\":\"Microscopic Self-Organization of Enzymic Reactions in Small Volumes\",\"authors\":\"A. Mikhailov, B. Hess\",\"doi\":\"10.1021/jp9616627\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Using an enzymic reaction with allosteric product activation as example, we show that allosterically regulated reactions in small volumes may develop strong microscopic correlations between individual molecular reaction events. Such correlations lead to coherent synchronous activity of the enzymic molecular population which is revealed in frequent periodic spiking of the reaction. </p>\",\"PeriodicalId\":58,\"journal\":{\"name\":\"The Journal of Physical Chemistry \",\"volume\":\"100 49\",\"pages\":\"19059–19065\"},\"PeriodicalIF\":2.7810,\"publicationDate\":\"1996-12-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1021/jp9616627\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Physical Chemistry \",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/jp9616627\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Physical Chemistry ","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/jp9616627","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microscopic Self-Organization of Enzymic Reactions in Small Volumes
Using an enzymic reaction with allosteric product activation as example, we show that allosterically regulated reactions in small volumes may develop strong microscopic correlations between individual molecular reaction events. Such correlations lead to coherent synchronous activity of the enzymic molecular population which is revealed in frequent periodic spiking of the reaction.
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