通过阻断 PD-1 通路重新激活衰竭的 T 细胞

Junghwa Lee, Eunseon Ahn, Haydn T Kissick, Rafi Ahmed
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引用次数: 0

摘要

抗原持续刺激导致的T细胞衰竭是慢性病毒感染和癌症的一个主要特征。程序性细胞死亡-1(PD-1)是T细胞衰竭的主要调节因子,阻断PD-1通路可恢复T细胞功能,改善病原体控制和肿瘤根除。以 PD-1 抑制受体通路为靶点的免疫疗法已显示出显著的抗肿瘤活性。最近,阻断 PD-1 的抗体已被批准用于癌症患者。在这篇综述中,我们总结了 PD-1 通路在慢性感染和癌症中的作用,以及 PD-1 引导的免疫疗法在慢性感染或癌症患者中的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway.

Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway.

Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway.

T-cell exhaustion due to persistent antigen stimulation is a key feature of chronic viral infections and cancer. Programmed cell death-1 (PD-1) is a major regulator of T-cell exhaustion, and blocking the PD-1 pathway restores T-cell function and improves pathogen control and tumor eradication. Immunotherapy targeting the PD-1 inhibitory receptor pathway has demonstrated significant antitumor activity. Recently, antibodies blocking PD-1 have been approved for use in cancer patients. In this review, we summarize the role of the PD-1 pathway in chronic infection and cancer and the therapeutic potential of PD-1-directed immunotherapy in patients with chronic infection or cancer.

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