干眼病发病率与慢性移植物宿主病相关:非同期队列研究(美国眼科学会论文)。

Shahzad I Mian, Paola De la Parra-Colín, Rafael De Melo-Franco, Christopher Johnson, Tonatiuh Barrientos-Gutierrez
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引用次数: 0

摘要

目的:确定同种异体造血干细胞移植(HSCT)后慢性移植物抗宿主病(cGVHD)是否与稳定或进行性干眼病相关,并确定无干眼病病史患者的真实发病率。方法:在单一机构进行一项非并发队列研究,纳入136例HSCT前无干眼病史的患者。生存分析用于估计干眼病的发病率。发病率的计算使用生命表作为观察到的干眼病病例数除以队列中累积的人时间风险。从移植时间到诊断时间,再到最后一次就诊记录,计算转移概率。结果:干眼病发病率为0.8例/人/年,半数高危人群在移植后10个月内发生干眼病。发生干眼病的时间为轻度干眼病2.5个月,中度干眼病9.6个月,重度干眼病13.2个月。在累积发病率方面,73%的受试者在诊断时出现干眼病(50%为轻度,16%为中度,7%为重度)。结论:我们的研究结果表明,与cGVHD相关的干眼病是一种极其频繁的事件,其严重程度范围广泛,HSCT后早期出现轻度形式,晚期出现中度至重度形式。这些发现需要进一步研究,以阐明这是两种不同的病理生理实体,还是同一病理的不同表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dry Eye Disease Incidence Associated with Chronic Graft-Host Disease: Nonconcurrent Cohort Study (An American Ophthalmological Society Thesis).

Dry Eye Disease Incidence Associated with Chronic Graft-Host Disease: Nonconcurrent Cohort Study (An American Ophthalmological Society Thesis).

Dry Eye Disease Incidence Associated with Chronic Graft-Host Disease: Nonconcurrent Cohort Study (An American Ophthalmological Society Thesis).

Dry Eye Disease Incidence Associated with Chronic Graft-Host Disease: Nonconcurrent Cohort Study (An American Ophthalmological Society Thesis).

Purpose: To determine if chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with stable or progressive dry eye disease and to determine the true incidence in patients with no prior history of dry eye disease.

Methods: A nonconcurrent cohort study at a single institution with 136 patients who had no previous history of dry eye disease before HSCT. Survival analysis was used to estimate dry eye disease incidence. The incidence rate was calculated using life tables as the number of observed dry eye disease cases divided by the person-time at risk accumulated by the cohort. Transition probabilities were calculated from time of transplant to time of diagnosis, and then to last recorded visit.

Results: Incidence rate was 0.8 cases of dry eye disease per person-year, and half of the population at risk developed dry eye disease during the first 10 months post transplant. Time to develop dry eye disease was 2.5 months for mild dry eye disease, 9.6 months for moderate dry eye disease, and 13.2 months for severe dry eye disease. In terms of cumulative incidence, 73% of subjects developed dry eye disease (50% mild, 16% moderate, and 7% severe) at the time of diagnosis.

Conclusions: Our findings suggest that dry eye disease associated with cGVHD is an extremely frequent event and shows a wide spectrum of severity, with a mild form presenting early and a moderate to severe form presenting later after HSCT. These findings need to be studied further to elucidate if these are two different pathophysiological entities or just different expressions of the same pathology.

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