Luciana Bento-de-Souza , Jefferson R. Victor , Luiz C. Bento-de-Souza , Magaly Arrais-Santos , Andréia C. Rangel-Santos , Érica Pereira-Costa , Elaine Raniero-Fernandes , Maria I. Seixas-Duarte , João B. Oliveira-Filho , Alberto J. Silva Duarte
{"title":"编码notch受体和配体的基因在人胸腺发育中的淋巴细胞、nTreg细胞和树突状细胞的组成性表达","authors":"Luciana Bento-de-Souza , Jefferson R. Victor , Luiz C. Bento-de-Souza , Magaly Arrais-Santos , Andréia C. Rangel-Santos , Érica Pereira-Costa , Elaine Raniero-Fernandes , Maria I. Seixas-Duarte , João B. Oliveira-Filho , Alberto J. Silva Duarte","doi":"10.1016/j.rinim.2016.04.001","DOIUrl":null,"url":null,"abstract":"<div><p>The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.</p></div>","PeriodicalId":89845,"journal":{"name":"Results in immunology","volume":"6 ","pages":"Pages 15-20"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rinim.2016.04.001","citationCount":"16","resultStr":"{\"title\":\"Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus\",\"authors\":\"Luciana Bento-de-Souza , Jefferson R. Victor , Luiz C. Bento-de-Souza , Magaly Arrais-Santos , Andréia C. Rangel-Santos , Érica Pereira-Costa , Elaine Raniero-Fernandes , Maria I. Seixas-Duarte , João B. Oliveira-Filho , Alberto J. Silva Duarte\",\"doi\":\"10.1016/j.rinim.2016.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.</p></div>\",\"PeriodicalId\":89845,\"journal\":{\"name\":\"Results in immunology\",\"volume\":\"6 \",\"pages\":\"Pages 15-20\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.rinim.2016.04.001\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Results in immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211283916300041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Results in immunology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211283916300041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus
The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
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