从全血中分离循环肿瘤细胞的高通量微流控装置

Micro total analysis systems : proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference) Pub Date : 2015-10-01

Daniel K Yang, Serena Leong, Lydia L Sohn

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引用次数: 0

摘要

循环肿瘤细胞（CTCs）是确定癌症患者预后和跟踪疾病对治疗反应的有前途的标记物。我们介绍了自己开发的一种多级微流体设备，该设备利用惯性力和迪安阻力从全血中分离出 CTC。在对全血中的 MCF-7 GFP 细胞进行筛查时，我们展示了该装置 94.2% ± 2.1% 的癌细胞回收率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood.

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High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood.

Circulating tumor cells (CTCs) are promising markers to determine cancer patient prognosis and track disease response to therapy. We present a multi-stage microfluidic device we have developed that utilizes inertial and Dean drag forces for isolating CTCs from whole blood. We demonstrate a 94.2% ± 2.1% recovery of cancer cells with our device when screening whole blood spiked with MCF-7 GFP cells.

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Micro total analysis systems : proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference)

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