功能神经影像学在意识障碍诊断和预后应用中的挑战和缺陷。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2016-05-13 eCollection Date: 2016-01-01 DOI:10.2174/1874440001610010023
Yelena G Bodien, Joseph T Giacino
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引用次数: 9

摘要

目前对意识障碍患者的诊断评估多基于临床床边检测,对意识意识程度的评估容易出现较高的错误率。研究更客观的评估策略,如使用功能磁共振成像(fMRI)来检测意识意识,在研究界正变得越来越流行。然而,使用功能磁共振成像的固有挑战威胁到其作为诊断工具的有效性,需要在其融入临床环境之前得到解决。这些挑战包括从患者样本的异质性到影响数据采集的因素和解释策略中的偏差,下文将进行讨论。提出了旨在减轻某些限制的建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and Pitfalls Associated with Diagnostic and Prognostic Applications of Functional Neuroimaging in Disorders of Consciousness.

The diagnostic assessment of patients with disorder of consciousness is currently based on clinical testing at the bedside and prone to a high error rate in the assessment of the degree of conscious awareness. Investigation of more objective assessment strategies, such as the use of functional magnetic resonance imaging (fMRI) to detect conscious awareness, are becoming increasingly popular in the research community. However, inherent challenges to the use of fMRI threaten its validity as a diagnostic tool and will need to be resolved prior to its integration into the clinical setting. These challenges, which range from the heterogeneity of the patient sample to factors influencing data acquisition and biases in interpretation strategies, are discussed below. Recommendations aimed at mitigating some of the limitations are provided.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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