端粒长度动力学整合到系统生物学框架:综述。

Gene regulation and systems biology Pub Date : 2016-06-16 eCollection Date: 2016-01-01 DOI:10.4137/GRSB.S39836
Lilit Nersisyan
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引用次数: 3

摘要

端粒长度动力学在细胞过程和细胞命运的调控中起着至关重要的作用。与揭示端粒长度与年龄、年龄相关疾病和癌症相关的流行病学研究相反,端粒在调节转录组和表观基因组中的作用以及基因组变异在端粒延长中的作用尚未得到广泛分析。这是因为端粒长度测量的实验分析是消耗资源的,并且很少有高通量基因组学、转录组学和/或表观基因组学实验与端粒长度测量相结合的研究。从全基因组测序数据中评估端粒长度的计算方法的最新发展为将端粒整合到高通量系统生物学分析框架中提供了新的视角。在此,我们回顾了现有的端粒长度测量方法,并将它们与计算方法进行了比较,并讨论了它们在端粒长度动力学大规模研究中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integration of Telomere Length Dynamics into Systems Biology Framework: A Review.
Telomere length dynamics plays a crucial role in regulation of cellular processes and cell fate. In contrast to epidemiological studies revealing the association of telomere length with age, age-related diseases, and cancers, the role of telomeres in regulation of transcriptome and epigenome and the role of genomic variations in telomere lengthening are not extensively analyzed. This is explained by the fact that experimental assays for telomere length measurement are resource consuming, and there are very few studies where high-throughput genomics, transcriptomics, and/or epigenomics experiments have been coupled with telomere length measurements. Recent development of computational approaches for assessment of telomere length from whole genome sequencing data pave a new perspective on integration of telomeres into high-throughput systems biology analysis framework. Herein, we review existing methodologies for telomere length measurement and compare them to computational approaches, as well as discuss their applications in large-scale studies on telomere length dynamics.
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