微流控通道在被动给药中的扩散特性研究。

Journal of drug delivery Pub Date : 2016-01-01 Epub Date: 2016-05-26 DOI:10.1155/2016/7913616
Marcus J Goudie, Alyssa P Ghuman, Stephanie B Collins, Ramana M Pidaparti, Hitesh Handa
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引用次数: 5

摘要

由于能够轻松地创建复杂的设备设计,其特征尺寸可达10微米,因此微流体具有许多药物输送应用。在这项工作中,研究了用于治疗青光眼、年龄相关性黄斑变性(AMD)和糖尿病视网膜病变等眼部疾病的植入式设备的三种不同微通道设计。器件使用聚二甲基硅氧烷(PDMS)和软光刻技术制造,其中使用2-[甲氧基(聚乙烯氧基)丙基]三甲氧基硅烷(peg -硅烷)改变通道的表面化学性质。通过染料和各自药物的扩散系数之比,估计每个装置的一些常见药物的估计递送率。在生理条件下保持模型药物的递送速率,并在两周内记录通道设计和表面化学对模型药物递送速率的影响。结果表明,该装置的表面化学性质对模型药物的递送率无显著影响。所有设计都成功地为每种模型药物提供恒定的日剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications.

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications.

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications.

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications.

Microfluidics has many drug delivery applications due to the ability to easily create complex device designs with feature sizes reaching down to the 10s of microns. In this work, three different microchannel designs for an implantable device are investigated for treatment of ocular diseases such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. Devices were fabricated using polydimethylsiloxane (PDMS) and soft lithography techniques, where surface chemistry of the channels was altered using 2-[methoxy(polyethyleneoxy)propyl]trimethoxysilane (PEG-silane). An estimated delivery rate for a number of common drugs was approximated for each device through the ratio of the diffusion coefficients for the dye and the respective drug. The delivery rate of the model drugs was maintained at a physiological condition and the effects of channel design and surface chemistry on the delivery rate of the model drugs were recorded over a two-week period. Results showed that the surface chemistry of the device had no significant effect on the delivery rate of the model drugs. All designs were successful in delivering a constant daily dose for each model drug.

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来源期刊
Journal of drug delivery
Journal of drug delivery PHARMACOLOGY & PHARMACY-
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