快速免疫层析ODK0501法检测鼻咽拭子肺炎链球菌抗原的初步报告

IF 2.3
Multidisciplinary Respiratory Medicine Pub Date : 2016-06-20 eCollection Date: 2016-01-01 DOI:10.1186/s40248-016-0060-5
Shoji Suzuki, Naoki Nishimura, Torahiko Jinta, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Noboru Uchiyama, Naohiko Chohnabayashi
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引用次数: 1

摘要

背景:早期识别和控制病原菌对肺炎的治疗具有重要意义。目前,有两种用于肺炎球菌肺炎的快速抗原检测试剂盒:一种使用尿液样本,另一种使用痰样本,名为RAPIRUN®S. pneumoniae。RAPIRUN®对儿科患者鼻咽拭子样本显示出高敏感性。在这项研究中,我们研究了RAPIRUN®对成人患者鼻咽拭子的作用。方法:选取2011年11月至2012年4月在圣路加国际医院诊断为肺炎的所有成年患者进行横断面研究。使用快速抗原检测试剂盒对患者的单口痰、鼻咽拭子和尿液样本进行调查。痰和血培养也进行了评估。我们比较了使用RAPIRUN和鼻咽拭子诊断的肺炎球菌肺炎患者与使用其他方法诊断的患者的特征。同时计算敏感性和特异性。结果:60例肺炎患者中有17例诊断为肺炎球菌性肺炎。在17例病例中,4例使用RAPIRUN和鼻咽拭子获得阳性检测结果。敏感性和特异性分别为23.5%和100%。结论:成人患者鼻咽拭子联合RAPIRUN诊断肺炎球菌性肺炎的敏感性低于其他比较方法。肺炎的病原鉴定不仅应使用痰培养或快速抗原检测试剂盒,还应使用临床特征或痰革兰氏染色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report.

Background: Early identification and control of pathogenic bacteria are important in the treatment of pneumonia. Currently, two rapid antigen detection kits for pneumococcal pneumonia are available: one uses urine samples and the other, named RAPIRUN® S. pneumoniae, uses sputum samples. RAPIRUN® has shown high sensitivity with nasopharyngeal swab samples from pediatric patients. In this study, we investigated the performance of RAPIRUN® with nasopharyngeal swabs from adult patients.

Methods: All adult patients diagnosed with pneumonia from November 2011 to April 2012 in St. Luke's International hospital were included in this cross-sectional study. Single sputum, nasopharyngeal swab, and urine samples obtained from patients were investigated using a rapid antigen detection kit. Sputum and blood cultures were also evaluated. We compared the characteristics of pneumococcal pneumonia patients diagnosed using RAPIRUN with a nasopharyngeal swab to those patients diagnosed using other methods. Sensitivity and specificity were also calculated.

Results: Seventeen out of 60 patients with pneumonia were diagnosed with pneumococcal pneumonia. In 4 out  of the 17 cases, a positive test result was obtained using RAPIRUN with a nasopharyngeal swab. The sensitivity and specificity were 23.5 and 100 %, respectively.

Conclusion: RAPIRUN performed with nasopharyngeal swabs from adult patients exhibited lower sensitivity for the diagnosis of pneumococcal pneumonia than the other compared methods. The causative pathogen of pneumonia should be identified using not only sputum cultures or rapid antigen detection kits but also clinical features or gram staining of sputum.

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来源期刊
Multidisciplinary Respiratory Medicine
Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine
自引率
0.00%
发文量
23
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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