纳米颗粒表面包衣剂的毒性:结构-细胞毒性关系。

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2016-07-02 DOI:10.1080/10590501.2016.1202762

Ying Zhang, Xiaoping Li, Hongtao Yu

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引用次数: 21

摘要

研究了金属纳米粒子、阳离子烷基溴化铵和阴离子烷基硫酸盐表面涂层对人体皮肤角质形成细胞(HaCaT)和血液T淋巴细胞(TIB-152)的作用。短链表面活性剂(C8)不具有细胞毒性，但随着链长的增加，其细胞毒性增加并在C12处趋于稳定，阳离子表面活性剂对细胞系和阴离子表面活性剂对TIB-152具有抑制作用，阴离子表面活性剂对HaCaT具有C14处的抑制作用。阳离子表面活性剂对HaCaT的毒性大于阴离子表面活性剂;而对TIB-152细胞具有相似的细胞毒性。二烷基和四烷基铵盐比单取代的更有细胞毒性。

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Toxicity of nanoparticle surface coating agents: Structure-cytotoxicity relationship.

Surface coating agents for metal nanoparticles, cationic alkyl ammonium bromides, and anionic alkyl sulfates were tested against human skin keratinocytes (HaCaT) and blood T lymphocytes (TIB-152). The surfactants of short chain (C8) are not cytotoxic, but as chain length increases, their cytotoxicity increases and levels off at C12 for cationic surfactants against both cell lines and for anionic surfactants against the TIB-152, but C14 for anionic surfactants against HaCaT. The cationic surfactants are more toxic than the anionic surfactants for HaCaT; while with similar cytotoxicity for TIB-152 cells. di- and tetra-Alkyl ammonium salts are more cytotoxic than the mono-substituted.

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.