尺寸分离金属加工液气溶胶颗粒中的内毒素。

Annals of Occupational Hygiene Pub Date : 2016-08-01 Epub Date: 2016-06-06 DOI:10.1093/annhyg/mew036
Anna Dahlman-Höglund, Åsa Lindgren, Inger Mattsby-Baltzer
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引用次数: 8

摘要

尽管努力改善机器周围的环境空气,但在金属加工行业工作的呼吸道症状患者正在增加。我们的目的是通过使用个人采样器Sioutas级联冲击器来分析金属加工液(MWF)气溶胶中大小分离的空气中颗粒的内毒素含量,比较过滤器类型,并将空气中内毒素的浓度与相应的MWF进行比较。在一项试验性实地研究中,在两个单独的机器大厅共收集了10次气溶胶,在每个站点平行使用玻璃纤维和聚四氟乙烯过滤器。空气传播的内毒素分布在各大小馏分中。虽然在最大粒径部分(72%,2.5-10µm)中发现了大部分内毒素,但在最小粒径部分(2.5-10µm)中检测到高达8%的空气传播内毒素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endotoxin in Size-Separated Metal Working Fluid Aerosol Particles.

Patients with airway symptoms working in metal working industries are increasing, despite efforts to improve the environmental air surrounding the machines. Our aim was to analyse the amount of endotoxin in size-separated airborne particles of metal working fluid (MWF) aerosol, by using the personal sampler Sioutas cascade impactor, to compare filter types, and to compare the concentration of airborne endotoxin to that of the corresponding MWFs. In a pilot field study, aerosols were collected in two separate machine halls on totally 10 occasions, using glass fibre and polytetrafluoroethylene (PTFE) filters in parallel at each station. Airborne endotoxin was distributed over all size fractions. While a major part was found in the largest size fraction (72%, 2.5-10 µm), up to 8% of the airborne endotoxin was detected in the smallest size fraction (<0.25 µm). Comparing the efficiency of the filter types, a significantly higher median endotoxin level was found with glass fibres filters collecting the largest particle-size fraction (1.2-fold) and with PTFE filters collecting the smallest ones (5-fold). The levels of endotoxin in the size-separated airborne particle fractions correlated to those of the MWFs supporting the aerosol-generating machines. Our study indicates that a significant part of inhalable aerosols of MWFs consists of endotoxin-containing particles below the size of intact bacteria, and thus small enough to readily reach the deepest part of the lung. Combined with other chemical irritants of the MWF, exposure to MWF aerosols containing endotoxin pose a risk to respiratory health problems.

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