糠酸莫米松鼻喷雾剂:系统综述。

IF 2.3
Multidisciplinary Respiratory Medicine Pub Date : 2016-05-02 eCollection Date: 2016-01-01 DOI:10.1186/s40248-016-0054-3
Desiderio Passali, Maria Carla Spinosi, Anna Crisanti, Luisa Maria Bellussi
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引用次数: 43

摘要

未标记:鼻、鼻咽和鼻窦的炎症性疾病(过敏性和非过敏性鼻炎,NARES;鼻鼻窦炎伴/不伴鼻息肉,腺样体肥大伴/不伴中耳受累)临床表现为症状和并发症,严重影响生活质量和医疗保健支出。鼻内给药皮质类固醇,快速,简单,不需要合作,是治疗患者的首选方法,优化他们的生活质量,同时最大限度地减少恶化和并发症的风险。在市场上可获得的不同外用类固醇中,我们对糠酸莫米松(MF)及其主要竞争对手的有效性和安全性进行了比较分析。通过Pub Med和Google Scholar搜索,并使用“糠酸莫米松”、“鼻炎”、“鼻窦炎”、“哮喘”、“息肉病”、“中耳炎伴渗液”和“腺样体肥大”作为条目,我们发现了344篇文章,其中300篇符合资格标准。考虑到相关性和出版日期,我们选取了40篇文章作为审查样本。MF治疗和/或预防季节性和常年性变应性鼻炎鼻症状的有效性已得到充分证实,证据水平为Ia。尽管尚未对MF进行特别评估,但局部类固醇是混合性鼻炎和NARES最合适的治疗方法。在急性鼻窦炎(ARS)中,证据支持将其作为单一治疗或抗生素辅助治疗以降低复发率,并减少相关处方和医疗咨询的使用。慢性鼻窦炎(CRS)合并鼻息肉病,MF可减小息肉大小、鼻塞、改善生活质量和嗅觉,对治疗日间咳嗽也有效。局部应用MF治疗特应性儿童腺样体肥大和中耳炎疗效显著。至于安全性,MF已经证明了良好的安全性:孕妇可以安全使用;没有显示对生长速度和肾上腺抑制的全身影响;长期服用该药后未观察到上皮厚度或萎缩的变化。结论:MF已被证明对鼻和副鼻窦炎症性疾病的治疗有效;与竞争对手相比,它表现出更好的症状控制;从长远来看,它是一种可靠的治疗方法,不仅因为它已被证明有效,而且因为它在市场上的安全性已经超过17年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mometasone furoate nasal spray: a systematic review.

Unlabelled: The inflammatory diseases of the nose, rhino-pharynx and paranasal sinuses (allergic and non allergic rhinitis, NARES; rhinosinusitis with/without nasal polyposis, adenoidal hypertrophy with/without middle ear involvement) clinically manifest themselves with symptoms and complications severely affecting quality of life and health care expenditure. Intranasal administration of corticosteroids, being fast, simple, and not requiring cooperation, is the preferred way to treat the patients, to optimize their quality of life, at the same time minimizing the risk of exacerbations and complications. Among the different topical steroids available on the market, we performed a comparative analysis in terms of effectiveness and safety between mometasone furoate (MF) and its main competitors. Searching through Pub Med and Google Scholar and using as entries "mometasone furoate", "rhinitis", "sinusitis", "asthma", "polyposis", "otitis media with effusion", and "adenoid hypertrophy" we found 344 articles, 300 of which met the eligibility criteria. Taking into account relevance and date of publication, a sample of 40 articles was considered for the review. MF effectiveness for treatment and/or prophylaxis of nasal symptoms in seasonal and perennial allergic rhinitis has been fully established with a level of evidence Ia. Even though it has not been assessed for MF in particular, topical steroids are the most appropriate treatment in mixed rhinitis and NARES. In acute rhinosinusitis (ARS) evidences support their use as mono-therapy or as adjuvant to antibiotics for reducing the recurrence rate, and decrease the usage of related prescriptions and medical consultations. In chronic rhinosinusitis (CRS) with Nasal polyposis, MF reduces polyps size, nasal congestion, improves quality of life and sense of smell and it is also effective in the treatment of daytime cough. The topical use of MF has great efficacy in the management of adenoidal hypertrophy and otitis media of atopic children. As regards the safety, MF has demonstrated an excellent safety profile: pregnant women can safely use it; no systemic effects on growth velocity and adrenal suppression have been shown; no changes in epithelial thickness or atrophy have been observed after long term administration of the drug.

Conclusions: MF has been demonstrated to be effective in the treatment of the inflammatory diseases of the nose and paranasal sinuses; when compared to its competitors it shows a greater symptom control; it is a reliable treatment in the long term thanks not only to its proven efficacy, but also to its safety being on the market since more than 17 years.

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来源期刊
Multidisciplinary Respiratory Medicine
Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine
自引率
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发文量
23
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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