血液代谢组学分析确定了双相情感障碍中柠檬酸循环、尿素循环和氨基酸代谢的异常

Noriko Yoshimi , Takashi Futamura , Keiji Kakumoto , Alireza M. Salehi , Carl M. Sellgren , Jessica Holmén-Larsson , Joel Jakobsson , Erik Pålsson , Mikael Landén , Kenji Hashimoto
{"title":"血液代谢组学分析确定了双相情感障碍中柠檬酸循环、尿素循环和氨基酸代谢的异常","authors":"Noriko Yoshimi ,&nbsp;Takashi Futamura ,&nbsp;Keiji Kakumoto ,&nbsp;Alireza M. Salehi ,&nbsp;Carl M. Sellgren ,&nbsp;Jessica Holmén-Larsson ,&nbsp;Joel Jakobsson ,&nbsp;Erik Pålsson ,&nbsp;Mikael Landén ,&nbsp;Kenji Hashimoto","doi":"10.1016/j.bbacli.2016.03.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD.</p></div><div><h3>Methods</h3><p>We quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n<!--> <!-->=<!--> <!-->54) and age-matched male healthy controls (n<!--> <!-->=<!--> <!-->39).</p></div><div><h3>Results</h3><p>After multivariate logistic regression, serum levels of pyruvate, <em>N</em>-acetylglutamic acid, α-ketoglutarate, and arginine were significantly higher in BD patients than in healthy controls. Conversely, serum levels of β-alanine, and serine were significantly lower in BD patients than in healthy controls. Chronic (4-weeks) administration of lithium or valproic acid to adult male rats did not alter serum levels of pyruvate, <em>N</em>-acetylglutamic acid, β-alanine, serine, or arginine, but lithium administration significantly increased serum levels of α-ketoglutarate.</p></div><div><h3>Conclusions</h3><p>The metabolomics analysis demonstrated altered serum levels of pyruvate, <em>N</em>-acetylglutamic acid, β-alanine, serine, and arginine in BD patients.</p></div><div><h3>General significance</h3><p>The present findings suggest that abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism play a role in the pathogenesis of BD.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2016.03.008","citationCount":"72","resultStr":"{\"title\":\"Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder\",\"authors\":\"Noriko Yoshimi ,&nbsp;Takashi Futamura ,&nbsp;Keiji Kakumoto ,&nbsp;Alireza M. Salehi ,&nbsp;Carl M. Sellgren ,&nbsp;Jessica Holmén-Larsson ,&nbsp;Joel Jakobsson ,&nbsp;Erik Pålsson ,&nbsp;Mikael Landén ,&nbsp;Kenji Hashimoto\",\"doi\":\"10.1016/j.bbacli.2016.03.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD.</p></div><div><h3>Methods</h3><p>We quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n<!--> <!-->=<!--> <!-->54) and age-matched male healthy controls (n<!--> <!-->=<!--> <!-->39).</p></div><div><h3>Results</h3><p>After multivariate logistic regression, serum levels of pyruvate, <em>N</em>-acetylglutamic acid, α-ketoglutarate, and arginine were significantly higher in BD patients than in healthy controls. Conversely, serum levels of β-alanine, and serine were significantly lower in BD patients than in healthy controls. Chronic (4-weeks) administration of lithium or valproic acid to adult male rats did not alter serum levels of pyruvate, <em>N</em>-acetylglutamic acid, β-alanine, serine, or arginine, but lithium administration significantly increased serum levels of α-ketoglutarate.</p></div><div><h3>Conclusions</h3><p>The metabolomics analysis demonstrated altered serum levels of pyruvate, <em>N</em>-acetylglutamic acid, β-alanine, serine, and arginine in BD patients.</p></div><div><h3>General significance</h3><p>The present findings suggest that abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism play a role in the pathogenesis of BD.</p></div>\",\"PeriodicalId\":72344,\"journal\":{\"name\":\"BBA clinical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.bbacli.2016.03.008\",\"citationCount\":\"72\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BBA clinical\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214647416300125\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BBA clinical","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214647416300125","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 72

摘要

背景双相情感障碍(BD)是一种严重的使人衰弱的精神疾病。然而,精确的生物学基础仍然未知,阻碍了寻找新的生物标志物。我们对心境稳定的男性BD患者(n = 54)和年龄匹配的男性健康对照(n = 39)的116种代谢物的血清水平进行了量化分析。结果经多因素logistic回归分析,BD患者血清丙酮酸、n -乙酰谷氨酸、α-酮戊二酸和精氨酸水平显著高于健康对照组。相反,BD患者的血清β-丙氨酸和丝氨酸水平明显低于健康对照组。成年雄性大鼠长期(4周)服用锂或丙戊酸并没有改变血清中丙酮酸、n -乙酰谷氨酸、β-丙氨酸、丝氨酸或精氨酸的水平,但服用锂可显著增加血清中α-酮戊二酸的水平。结论代谢组学分析表明,BD患者血清中丙酮酸、n -乙酰谷氨酸、β-丙氨酸、丝氨酸和精氨酸水平发生改变。本研究结果提示,柠檬酸循环、尿素循环和氨基酸代谢异常在BD的发病机制中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

Background

Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD.

Methods

We quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n = 54) and age-matched male healthy controls (n = 39).

Results

After multivariate logistic regression, serum levels of pyruvate, N-acetylglutamic acid, α-ketoglutarate, and arginine were significantly higher in BD patients than in healthy controls. Conversely, serum levels of β-alanine, and serine were significantly lower in BD patients than in healthy controls. Chronic (4-weeks) administration of lithium or valproic acid to adult male rats did not alter serum levels of pyruvate, N-acetylglutamic acid, β-alanine, serine, or arginine, but lithium administration significantly increased serum levels of α-ketoglutarate.

Conclusions

The metabolomics analysis demonstrated altered serum levels of pyruvate, N-acetylglutamic acid, β-alanine, serine, and arginine in BD patients.

General significance

The present findings suggest that abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism play a role in the pathogenesis of BD.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信