{"title":"结肠憩室出血增加及混杂因素。","authors":"Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Masakazu Washio","doi":"10.4292/wjgpt.v7.i3.440","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To classify changes over time in causes of lower gastrointestinal bleeding (LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage (DH).</p><p><strong>Methods: </strong>A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group (EG, 1995-2006, n = 828) and a late group (LG, 2007-2013, n = 975), and specific diseases were compared between groups. In addition, antithrombotic drug (ATD) use and nonsteroidal anti-inflammatory drug (NSAID) use were compared between patients with and without DH.</p><p><strong>Results: </strong>Older patients (≥ 70 years old) and those with colonic DH were more frequent in LG than in EG (P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity (body mass index ≥ 25 kg/m(2)), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without.</p><p><strong>Conclusion: </strong>Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients.</p>","PeriodicalId":23755,"journal":{"name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","volume":"7 3","pages":"440-6"},"PeriodicalIF":0.0000,"publicationDate":"2016-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986401/pdf/WJGPT-7-440.pdf","citationCount":"29","resultStr":"{\"title\":\"Increase in colonic diverticular hemorrhage and confounding factors.\",\"authors\":\"Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Shinichiro Maki, Kenta Chuman, Akihiro Koga, Kensei Ohtsu, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Masakazu Washio\",\"doi\":\"10.4292/wjgpt.v7.i3.440\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To classify changes over time in causes of lower gastrointestinal bleeding (LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage (DH).</p><p><strong>Methods: </strong>A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group (EG, 1995-2006, n = 828) and a late group (LG, 2007-2013, n = 975), and specific diseases were compared between groups. In addition, antithrombotic drug (ATD) use and nonsteroidal anti-inflammatory drug (NSAID) use were compared between patients with and without DH.</p><p><strong>Results: </strong>Older patients (≥ 70 years old) and those with colonic DH were more frequent in LG than in EG (P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity (body mass index ≥ 25 kg/m(2)), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without.</p><p><strong>Conclusion: </strong>Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients.</p>\",\"PeriodicalId\":23755,\"journal\":{\"name\":\"World Journal of Gastrointestinal Pharmacology and Therapeutics\",\"volume\":\"7 3\",\"pages\":\"440-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986401/pdf/WJGPT-7-440.pdf\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Gastrointestinal Pharmacology and Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4292/wjgpt.v7.i3.440\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Gastrointestinal Pharmacology and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4292/wjgpt.v7.i3.440","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 29
摘要
目的:分类下消化道出血(LGIB)的原因随时间的变化，并确定与憩室出血(DH)的发生率和特征变化相关的因素。方法:1995 - 2013年我院1803例显性LGIB患者行结肠镜检查。将患者分为早期组(EG, 1995-2006, n = 828)和晚期组(LG, 2007-2013, n = 975)，比较两组间的具体疾病情况。此外，比较了有DH和无DH患者的抗血栓药物(ATD)和非甾体抗炎药(NSAID)的使用情况。结果:老年(≥70岁)和结肠DH患者发生LG的频率高于EG (P < 0.01)。在DH患者中，使用ATDs和非甾体抗炎药、男性、肥胖(体重指数≥25 kg/m(2))、吸烟、饮酒和动脉硬化疾病的患者比非DH患者更常见。结论:结肠DH的发病率似乎随着人口的老龄化而增加，其相关因素包括ATDs和NSAIDs的使用、男性、肥胖、吸烟、饮酒和动脉硬化疾病。这些因素在处理DH患者时是有价值的。
Increase in colonic diverticular hemorrhage and confounding factors.
Aim: To classify changes over time in causes of lower gastrointestinal bleeding (LGIB) and to identify factors associated with changes in the incidence and characteristics of diverticular hemorrhage (DH).
Methods: A total of 1803 patients underwent colonoscopy for overt LGIB at our hospital from 1995 to 2013. Patients were divided into an early group (EG, 1995-2006, n = 828) and a late group (LG, 2007-2013, n = 975), and specific diseases were compared between groups. In addition, antithrombotic drug (ATD) use and nonsteroidal anti-inflammatory drug (NSAID) use were compared between patients with and without DH.
Results: Older patients (≥ 70 years old) and those with colonic DH were more frequent in LG than in EG (P < 0.01). Patients using ATDs as well as NSAIDs, male sex, obesity (body mass index ≥ 25 kg/m(2)), smoking, alcohol drinking, and arteriosclerotic diseases were more frequent in patients with DH than in those without.
Conclusion: Incidence of colonic DH seems to increase with aging of the population, and factors involved include use of ATDs and NSAIDs, male sex, obesity, smoking, alcohol drinking, and arteriosclerotic disease. These factors are of value in handling DH patients.
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