吸气分数作为COPD患者骨骼肌功能障碍的标志

P. Cebollero , F. Zambom-Ferraresi , M. Hernández , J. Hueto , J. Cascante , M.M. Anton
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引用次数: 15

摘要

背景:吸气量与总肺活量(IC/TLC)之比≤25%已成为慢性阻塞性肺疾病(COPD)患者较好的死亡率指标。IC/TLC比值与下肢骨骼肌功能的关系尚不清楚。方法将35例中重度COPD患者分为IC/TLC≤25%组(n = 16)和>25%组(n = 19)。测试了受试者的大腿肌肉质量体积(MMT)、最大力量、下肢功率输出和身体活动。结果IC/TLC中MMT总量;25%组明显低于(413.91±89.42 cm3) (p <0.001)比IC/TLC < 0.001;25%组(575.20±11.76 cm3)。在IC/TLC≤25%组中,下肢最大力量和下肢肌肉峰值输出功率降低36-56% (p <在IC/TLC >患者中,两者的差异为0.01);组的25%。结论:TLC /TLC≤25%与下肢最大力量和峰值功率输出降低有关。IC/TLC≤25%作为判断周围肌肉功能障碍的指标可能具有重要的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD

Background

An inspiratory capacity to total lung capacity (IC/TLC) ratio of ≤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown.

Methods

Thirty-five men with moderate to severe COPD were divided into those with IC/TLC  25% (n = 16) and >25% (n = 19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity.

Results

Total MMT in the IC/TLC < 25% group was significantly lower (413.91 ± 89.42 cm3) (p < 0.001) than in the IC/TLC > 25% group (575.20 ± 11.76 cm3). In the IC/TLC  25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36–56% lower (p < 0.01) than among the patients in the IC/TLC > 25% group.

Conclusion

IC/TLC  25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC  25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction.

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