P. Cebollero , F. Zambom-Ferraresi , M. Hernández , J. Hueto , J. Cascante , M.M. Anton
{"title":"吸气分数作为COPD患者骨骼肌功能障碍的标志","authors":"P. Cebollero , F. Zambom-Ferraresi , M. Hernández , J. Hueto , J. Cascante , M.M. Anton","doi":"10.1016/j.rppnen.2016.07.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>An inspiratory capacity to total lung capacity (IC/TLC) ratio of ≤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown.</p></div><div><h3>Methods</h3><p>Thirty-five men with moderate to severe COPD were divided into those with IC/TLC<!--> <!-->≤<!--> <!-->25% (<em>n</em> <!-->=<!--> <!-->16) and >25% (<em>n</em> <!-->=<!--> <!-->19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity.</p></div><div><h3>Results</h3><p>Total MMT in the IC/TLC<!--> <!--><<!--> <!-->25% group was significantly lower (413.91<!--> <!-->±<!--> <!-->89.42<!--> <!-->cm<sup>3</sup>) (<em>p</em> <!--><<!--> <!-->0.001) than in the IC/TLC<!--> <!-->><!--> <!-->25% group (575.20<!--> <!-->±<!--> <!-->11.76<!--> <!-->cm<sup>3</sup>). In the IC/TLC<!--> <!-->≤<!--> <!-->25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36–56% lower (<em>p</em> <!--><<!--> <!-->0.01) than among the patients in the IC/TLC<!--> <!-->><!--> <!-->25% group.</p></div><div><h3>Conclusion</h3><p>IC/TLC<!--> <!-->≤<!--> <!-->25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC<!--> <!-->≤<!--> <!-->25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2016.07.003","citationCount":"15","resultStr":"{\"title\":\"Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD\",\"authors\":\"P. Cebollero , F. Zambom-Ferraresi , M. Hernández , J. Hueto , J. Cascante , M.M. Anton\",\"doi\":\"10.1016/j.rppnen.2016.07.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>An inspiratory capacity to total lung capacity (IC/TLC) ratio of ≤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown.</p></div><div><h3>Methods</h3><p>Thirty-five men with moderate to severe COPD were divided into those with IC/TLC<!--> <!-->≤<!--> <!-->25% (<em>n</em> <!-->=<!--> <!-->16) and >25% (<em>n</em> <!-->=<!--> <!-->19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity.</p></div><div><h3>Results</h3><p>Total MMT in the IC/TLC<!--> <!--><<!--> <!-->25% group was significantly lower (413.91<!--> <!-->±<!--> <!-->89.42<!--> <!-->cm<sup>3</sup>) (<em>p</em> <!--><<!--> <!-->0.001) than in the IC/TLC<!--> <!-->><!--> <!-->25% group (575.20<!--> <!-->±<!--> <!-->11.76<!--> <!-->cm<sup>3</sup>). In the IC/TLC<!--> <!-->≤<!--> <!-->25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36–56% lower (<em>p</em> <!--><<!--> <!-->0.01) than among the patients in the IC/TLC<!--> <!-->><!--> <!-->25% group.</p></div><div><h3>Conclusion</h3><p>IC/TLC<!--> <!-->≤<!--> <!-->25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC<!--> <!-->≤<!--> <!-->25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction.</p></div>\",\"PeriodicalId\":101122,\"journal\":{\"name\":\"Revista Portuguesa de Pneumologia (English Edition)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.rppnen.2016.07.003\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Portuguesa de Pneumologia (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2173511516300896\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Portuguesa de Pneumologia (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173511516300896","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD
Background
An inspiratory capacity to total lung capacity (IC/TLC) ratio of ≤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown.
Methods
Thirty-five men with moderate to severe COPD were divided into those with IC/TLC ≤ 25% (n = 16) and >25% (n = 19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity.
Results
Total MMT in the IC/TLC < 25% group was significantly lower (413.91 ± 89.42 cm3) (p < 0.001) than in the IC/TLC > 25% group (575.20 ± 11.76 cm3). In the IC/TLC ≤ 25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36–56% lower (p < 0.01) than among the patients in the IC/TLC > 25% group.
Conclusion
IC/TLC ≤ 25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC ≤ 25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction.
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