基于适体体的人体体液生物标志物筛选。

Microarrays Pub Date : 2015-09-22 DOI:10.3390/microarrays4030424

Dania Albaba, Sanam Soomro, Chandra Mohan

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引用次数: 9

摘要

近年来，适体在高通量多路复用实验中逐渐取代抗体。这种基于适配体的生物标志物筛选技术始于2010年，能够在非常小的样本量中检测数千种蛋白质。有了这项新技术，研究人员希望通过筛选人体体液，找到临床上适合多种疾病的生物标志物。在这项工作中，我们回顾了八项利用适体生物标志物筛选人体体液的研究，并重点介绍了新发现的蛋白质生物标志物。

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Aptamer-Based Screens of Human Body Fluids for Biomarkers.

In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered.

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来源期刊

Microarrays

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： High-Throughput (formerly Microarrays, ISSN 2076-3905) is a multidisciplinary peer-reviewed scientific journal that provides an advanced forum for the publication of studies reporting high-dimensional approaches and developments in Life Sciences, Chemistry and related fields. Our aim is to encourage scientists to publish their experimental and theoretical results based on high-throughput techniques as well as computational and statistical tools for data analysis and interpretation. The full experimental or methodological details must be provided so that the results can be reproduced. There is no restriction on the length of the papers. High-Throughput invites submissions covering several topics, including, but not limited to: Microarrays, DNA Sequencing, RNA Sequencing, Protein Identification and Quantification, Cell-based Approaches, Omics Technologies, Imaging, Bioinformatics, Computational Biology/Chemistry, Statistics, Integrative Omics, Drug Discovery and Development, Microfluidics, Lab-on-a-chip, Data Mining, Databases, Multiplex Assays.