八面体钛(IV)异效(苯甲酰丙酮和羟肟酸)配合物的ct-DNA结合及抗菌活性。

International Journal of Medicinal Chemistry Pub Date : 2016-01-01 Epub Date: 2016-03-16 DOI:10.1155/2016/2361214
Raj Kaushal, Sheetal Thakur, Kiran Nehra
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引用次数: 8

摘要

五种结构相关的钛(IV)异眠配合物[TiCl2(bzac)(L(1-4))]和[TiCl3(bzac)(HL(5))];苯甲酰丙酮;以L(1-5) =苯并氢ximate (L(1))、水杨酸氢ximate (L(2))、乙酰氢ximate (L(3))、羟基脲(L(4))和n -苯甲酰- n -苯基羟胺(L(5))对10种病原菌的抑菌活性进行了评价。用琼脂孔扩散法测定钛(IV)配合物(1-5)的抗菌性能显著。采用紫外-可见吸收光谱技术研究钛(IV)配合物与小牛胸腺DNA (ct-DNA)的结合性质。紫外-可见吸收光谱结果表明,ct-DNA与钛(IV)配合物的相互作用可能通过相同的模式发生。结果表明,钛(IV)配合物可以通过插入模式与小牛胸腺DNA (ct-DNA)结合。利用Benesi-Hildebrand方程计算了吸收光谱的本征结合常数kb。此外,还计算了所有配合物的吉布斯自由能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes.

ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes.

ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes.

ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes.

Five structurally related titanium (IV) heteroleptic complexes, [TiCl2(bzac)(L(1-4))] and [TiCl3(bzac)(HL(5))]; bzac = benzoylacetonate; L(1-5) = benzohydroximate (L(1)), salicylhydroximate (L(2)), acetohydroximate (L(3)), hydroxyurea (L(4)), and N-benzoyl-N-phenyl hydroxylamine (L(5)), were used for the assessment of their antibacterial activities against ten pathogenic bacterial strains. The titanium (IV) complexes (1-5) demonstrated significant level of antibacterial properties as measured using agar well diffusion method. UV-Vis absorption spectroscopic technique was applied, to get a better insight into the nature of binding between titanium (IV) complexes with calf thymus DNA (ct-DNA). On the basis of the results of UV-Vis absorption spectroscopy, the interaction between ct-DNA and the titanium (IV) complexes is likely to occur through the same mode. Results indicated that titanium (IV) complex can bind to calf thymus DNA (ct-DNA) via an intercalative mode. The intrinsic binding constant (K b ) was calculated by absorption spectra by using Benesi-Hildebrand equation. Further, Gibbs free energy was also calculated for all the complexes.

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期刊介绍: International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.
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