KTXXXW基序远端的卷曲-4 c -末端对于正常的散乱招募和norrin刺激的left / tcf依赖性转录激活至关重要。

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Molecular Signaling Pub Date : 2016-02-05 DOI:10.5334/1750-2187-11-1

Alexander C Bertalovitz, Milly S Pau, Shujuan Gao, Craig C Malbon, Hsien-Yu Wang

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引用次数: 14

摘要

G蛋白偶联受体(GPCR)的羧基(C)端决定其基本功能。Frizzleds (FZD)的KTXXXW基序c端与disheveled (DVL)的募集有关。通过对FZD4及其相关配体Norrin的研究，我们发现frizzed -4 c端末端KTXXXW基序远端至少有3个残基对于DVL的募集和Norrin对left / tcf依赖性转录激活至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation.

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Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation.

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.

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来源期刊

Journal of Molecular Signaling Biochemistry, Genetics and Molecular Biology-Biochemistry

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期刊介绍： Journal of Molecular Signaling is an open access, peer-reviewed online journal that encompasses all aspects of molecular signaling. Molecular signaling is an exponentially growing field that encompasses different molecular aspects of cell signaling underlying normal and pathological conditions. Specifically, the research area of the journal is on the normal or aberrant molecular mechanisms involving receptors, G-proteins, kinases, phosphatases, and transcription factors in regulating cell proliferation, differentiation, apoptosis, and oncogenesis in mammalian cells. This area also covers the genetic and epigenetic changes that modulate the signaling properties of cells and the resultant physiological conditions.