V I Pustovoit, E Ya Adoeva, S S Kozlov, V S Turitsin, A F Nikitin
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[MORPHOLOGICAL CHANGES IN THE STRIATED MUSCLES AFTER ALBENDAZOLE TREATMENT FOR EXPERIMENTAL TRICHINOSIS].
Trichinosis was experimentally induced in rats. The morphology of encystation of Trichinella larvae was studied in the striated muscles. The efficacy of albendazole was evaluated in different intensity of Trichinella larvae infestation in the striated muscles of the laboratory animals. Encystation was shown to cease at 21 days. Albendazole showed high activity against intestinal and encapsulated larvae of Trichinella, leading to 100% death of T. spiralis. Capsules and Trichinella larvae were described to be destructed after treatment with albendazole 15 mg/kg twice daily for 10 days.
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