Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda
{"title":"含1,3,4-恶二唑基团苯并咪唑类抗癌药物的合成。","authors":"Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda","doi":"10.7598/cst2015.1029","DOIUrl":null,"url":null,"abstract":"<p><p>In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (<b>5a-i</b>) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (<b>5c</b>) exhibited moderate cytotoxicity.</p>","PeriodicalId":10087,"journal":{"name":"Chemical science transactions","volume":"4 2","pages":"534-540"},"PeriodicalIF":0.0000,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594831/pdf/nihms702132.pdf","citationCount":"12","resultStr":"{\"title\":\"Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.\",\"authors\":\"Bereket Mochona, Elizabeth Mazzio, Madhavei Gangapurum, Nelly Mateeva, K K Redda\",\"doi\":\"10.7598/cst2015.1029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (<b>5a-i</b>) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (<b>5c</b>) exhibited moderate cytotoxicity.</p>\",\"PeriodicalId\":10087,\"journal\":{\"name\":\"Chemical science transactions\",\"volume\":\"4 2\",\"pages\":\"534-540\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594831/pdf/nihms702132.pdf\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical science transactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7598/cst2015.1029\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical science transactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7598/cst2015.1029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents.
In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (5a-i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (5c) exhibited moderate cytotoxicity.