白色念珠菌多药转运蛋白Cdr1的abc。

Eukaryotic Cell Pub Date : 2015-12-01 Epub Date: 2015-09-25 DOI:10.1128/EC.00137-15
Rajendra Prasad, Atanu Banerjee, Nitesh Kumar Khandelwal, Sanjiveeni Dhamgaye
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引用次数: 78

摘要

鉴于病原菌和癌细胞之间的多药耐药(MDR),膜转运蛋白具有深远的临床意义。到目前为止,化疗失败主要归因于这些蛋白质的强大和多样化,它们无处不在,存在于生命世界的每个阶层。白色念珠菌是影响免疫功能低下患者的主要真菌病原体之一,在化疗过程中也会发生耐多药。白色念珠菌作为发展耐多药的策略之一所利用的关键膜转运蛋白属于ATP结合盒(ABC)或主要促进剂超家族(MFS)一类蛋白。ABC转运蛋白念珠菌耐药1蛋白(Cdr1p)是这些转运蛋白中的主要参与者,它使病原体能够战胜它所遇到的抗真菌药。混杂的Cdr1蛋白满足了研究多药转运蛋白调控的分子机制和不对称ABC转运蛋白结构功能分析的典型模型需求。在这篇综述中,我们介绍了二十年来Cdr1p研究的亮点,这些研究为研究Cdr1p的结构-功能关系和调控回路提供了一个平台,以便更好地了解酵母和其他生物的MDR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The ABCs of Candida albicans Multidrug Transporter Cdr1.

The ABCs of Candida albicans Multidrug Transporter Cdr1.

The ABCs of Candida albicans Multidrug Transporter Cdr1.

The ABCs of Candida albicans Multidrug Transporter Cdr1.

In the light of multidrug resistance (MDR) among pathogenic microbes and cancer cells, membrane transporters have gained profound clinical significance. Chemotherapeutic failure, by far, has been attributed mainly to the robust and diverse array of these proteins, which are omnipresent in every stratum of the living world. Candida albicans, one of the major fungal pathogens affecting immunocompromised patients, also develops MDR during the course of chemotherapy. The pivotal membrane transporters that C. albicans has exploited as one of the strategies to develop MDR belongs to either the ATP binding cassette (ABC) or the major facilitator superfamily (MFS) class of proteins. The ABC transporter Candida drug resistance 1 protein (Cdr1p) is a major player among these transporters that enables the pathogen to outplay the battery of antifungals encountered by it. The promiscuous Cdr1 protein fulfills the quintessential need of a model to study molecular mechanisms of multidrug transporter regulation and structure-function analyses of asymmetric ABC transporters. In this review, we cover the highlights of two decades of research on Cdr1p that has provided a platform to study its structure-function relationships and regulatory circuitry for a better understanding of MDR not only in yeast but also in other organisms.

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来源期刊
Eukaryotic Cell
Eukaryotic Cell 生物-微生物学
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审稿时长
1 months
期刊介绍: Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology
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