[从化学药剂学到药理学的Magendie公式汇编(1821-1840)]。

Histoire des sciences medicales Pub Date : 2015-04-01
Alain Ségal, Francis Trépardoux
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引用次数: 0

摘要

从1821年到1836年,《处方手册》连续出版了9期,由Magendie构思为医疗处方的常用工具,最初专门用于新的化学药物,主要是从原料中提取的纯碱、士的宁、奎宁和吗啡。此外,他还包括矿物化学物质、氢氰酸盐、碘和溴,所有这些都得到了Pelletier、Caventou和其他人的新成果的支持。Magendie在动物实验方面非常熟练,开发并标准化了这些新成分的活性和安全程度评估。它明确地预见了20世纪新药注册法律所确定的评价计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The Formulaires of Magendie (1821-1840) of the chemical pharmacy to pharmacology].

With nine consecutive issues published from 1821 to 1836, the Formulaire concepted by Magendie as a usual tool for the medical precriptions, was first dedicated to the new chemical pharmaceuticals, mainly the pure alcaloids, strychnine, quinine and morphine, extracted from raw products. As well he included mineral chemicals, hydrocyanates, iodine and bromide, all supported by newly achieved works, from Pelletier, Caventou and others. Magendie perfectly skilled in animal experimentation, developped and standardized the as far as to evaluate the activity and safety degrees of these new components. It clearly anticipated the evaluation plan determined by the law for the registration of the new drugs in the twentieth century.

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