Tamas Fulop, Janet McElhaney, Graham Pawelec, Alan A Cohen, José A Morais, Gilles Dupuis, Sarra Baehl, Xavier Camous, Jacek M Witkowski, Anis Larbi
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Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms and strategies for assessing frailty syndrome, but currently, no universally accepted definition or measurement protocol has been determined. Consequently, the biological cause(s) of frailty are also poorly defined. Much circumstantial experimental data point to the dysregulation of several key physiological systems, including the neuroendocrine, musculoskeletal, metabolic and immune/inflammatory systems, resulting from alterations in functional reserves. Immune dysregulation and inflammation as causes of frailty have gained some support from the results of longitudinal studies, but a true causal relationship has not been established. This chapter will describe the immune/inflammatory alterations found in frailty and their putative causal relationships with this state.
期刊介绍：
At a time when interest in the process of aging is driving more and more research, ''Interdisciplinary Topics in Gerontology and Geriatrics'' offers investigators a way to stay at the forefront of developments. This series represents a comprehensive and integrated approach to the problems of aging and presents pertinent data from studies in animal and human gerontology. In order to provide a forum for a unified concept of gerontology, both the biological foundations and the clinical and sociological consequences of aging in humans are presented. Individual volumes are characterized by an analytic overall view of the aging process, novel ideas, and original approaches to healthy aging as well as age-related functional decline.
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