结节性痤疮缺乏维生素D的初步证据。

Dermato-Endocrinology Pub Date : 2015-01-14 eCollection Date: 2014-01-01 DOI:10.4161/derm.29799
Mustafa Turgut Yildizgören, Arzu Karatas Togral
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引用次数: 33

摘要

目的:寻常痤疮是一种慢性炎症性疾病,其发病机制与激素影响、毛囊堵塞和毛囊角化过度、皮脂分泌增加、痤疮丙酸杆菌定植和炎症有关。最近,有大量证据表明维生素D具有溶解粉刺的特性,它可以调节免疫系统,调节皮脂细胞和角质形成细胞的增殖和分化,还可以作为一种抗氧化剂。在这项研究中,我们旨在比较一组结节性痤疮患者的血清维生素D水平与一组对照组的维生素D水平,以确定维生素D与痤疮之间是否存在任何关系。方法:测定43例新诊断结节性痤疮患者和46例健康对照者的25[OH]D水平,并根据25[OH]D水平分为正常/充足(>20 ng/mL)和不足/缺乏(结果:纳入43例患者和46例对照者,平均年龄分别为23.13(±5.78)岁和25.23(±4.73)岁。两组患者体重指数及钙、磷、ALP、甲状旁腺素水平无显著差异。结节性痤疮患者血清25[OH]D水平明显低于对照组(P< 0.05)。结论:结节性痤疮患者血清维生素D水平较对照组低。这项研究的结果表明,维生素D水平低和痤疮之间存在联系。需要更大规模的流行病学研究来证实痤疮患者体内维生素D水平的状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preliminary evidence for vitamin D deficiency in nodulocystic acne.

Objective: Acne vulgaris is a chronic inflammatory disease, and hormonal influences, follicular plugging and follicular hyperkeratinization, increased sebum secretion, Propionibacterium acnes colonization, and inflammation are involved in its pathogenesis. Recently, a significant body of evidence has accumulated that describes the comedolytic properties of vitamin D and its roles as a modulator of the immune system, a regulator of the proliferation and differentiation of sebocytes and keratinocytes, and as an antioxidant. In this study, we aimed to compare serum vitamin D levels in a group of patients with nodulocystic acne with vitamin D levels in a group of control subjects to determine whether there was any relationship between the vitamin D and acne.

Methods: Levels of 25-hydroxyvitamin D (25[OH]D) were measured in 43 patients with newly diagnosed nodulocystic acne and in 46 healthy control subjects, and participants were grouped according to their 25[OH]D levels as follows: normal/sufficient (>20 ng/mL) or insufficient/deficient (<20 ng/mL). Serum concentrations of calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and parathyroid hormone (PTH) were measured.

Results: Forty-three patients and 46 control individuals, with mean ages of 23.13 (± 5.78) years and 25.23 (± 4.73) years, respectively, were included in this study. There were no significant differences between the groups in relation to their body mass indices and Ca, P, ALP, and PTH levels. However, the patients with nodulocystic acne had significantly lower 25[OH]D levels than the subjects in the control group (P< 0.05).

Conclusion: The patients with nodulocystic acne had relatively low serum vitamin D levels compared with the subjects in the control group. The findings from this study suggest that there is a connection between low vitamin D levels and acne. Larger epidemiologic studies are needed to confirm the status of vitamin D levels in patients with acne.

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