静脉血栓栓塞与肺癌:综述。

IF 2.3
Multidisciplinary Respiratory Medicine Pub Date : 2015-09-15 eCollection Date: 2015-01-01 DOI:10.1186/s40248-015-0021-4
Carolina Vitale, Maria D'Amato, Paolo Calabrò, Anna Agnese Stanziola, Mauro Mormile, Antonio Molino
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引用次数: 57

摘要

静脉血栓栓塞(Venous thromboembolism, VTE)是恶性肿瘤的常见并发症,流行病学研究表明肺癌属于VTE发病率最高的恶性肿瘤群体。肺癌患者静脉血栓栓塞的危险因素有腺癌、非小细胞肺癌(与小细胞肺癌相比)、晚期疾病、全肺切除术、包括抗血管生成治疗在内的化疗。其他危险因素是预处理血小板计数和tf阳性微粒释放增加。d -二聚体水平升高并不一定表明静脉血栓栓塞的风险增加,但已被证明可以预测肺癌患者更糟糕的临床结果。肺癌患者静脉血栓形成增加的机制尚不清楚。目前还没有生物标志物被认为是肺癌患者静脉血栓栓塞的预测因子。虽然一些临床试验已经报道了抗血栓预防对接受化疗的肺癌患者的疗效,但由于这些患者发生血栓栓塞的风险增加,需要进一步的试验来评估临床益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Venous thromboembolism and lung cancer: a review.

Venous thromboembolism (VTE) is a common complication of malignancies and epidemiological studies suggest that lung cancer belonged to the group of malignancies with the highest incidence rates of VTE. Risk factors for VTE in lung cancer patients are adenocarcinoma, NSCLC in comparison with SCLC, advanced disease, pneumonectomy, chemotherapy including antiangiogenic therapy. Other risk factors are pretreatment platelet counts and increased release of TF-positive microparticles. Elevated D-dimer levels do not necessarily indicate an increased risk of VTE but have been shown to be predictive for a worse clinical outcome in lung cancer patients. Mechanisms responsible for the increase in venous thrombosis in patients with lung cancer are not understood. Currently no biomarker is recognized as a predictor for VTE in lung cancer patients. Although several clinical trials have reported the efficacy of antithrombotic prophylaxis in patients with lung cancer who are receiving chemotherapy, further trials are needed to assess the clinical benefit since these patients are at an increased risk of developing a thromboembolism.

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来源期刊
Multidisciplinary Respiratory Medicine
Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine
自引率
0.00%
发文量
23
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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