国际小鼠品系资源(IMSR):编目全球小鼠和胚胎干细胞系资源。

Janan T Eppig, Howie Motenko, Joel E Richardson, Beverly Richards-Smith, Cynthia L Smith
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引用次数: 52

摘要

获得高质量的遗传定义的、健康状况已知的小鼠资源对生物医学研究至关重要。通过确保用于研究实验的小鼠在生物学、遗传学和健康状况上是等同的,我们实现了知识转移、基于多个数据流的假设构建和基于公共小鼠资源(试剂)的实验可重复性。随着时间的推移,鼠标资源的主要存储库已经开发出来,每个存储库都有重要的独特资源可以提供。在这里,我们(a)描述了国际小鼠品系资源,它为用户提供了一个全球小鼠资源(活的、冷冻保存的、胚胎干细胞)的组合目录,可以直接访问保存感兴趣资源的存储库站点;(b)讨论了在统一小鼠资源目录中仍然存在挑战的资源之间的命名标准的承诺。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources.

The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources.

The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources.

The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources.

The availability of and access to quality genetically defined, health-status known mouse resources is critical for biomedical research. By ensuring that mice used in research experiments are biologically, genetically, and health-status equivalent, we enable knowledge transfer, hypothesis building based on multiple data streams, and experimental reproducibility based on common mouse resources (reagents). Major repositories for mouse resources have developed over time and each has significant unique resources to offer. Here we (a) describe The International Mouse Strain Resource that offers users a combined catalog of worldwide mouse resources (live, cryopreserved, embryonic stem cells), with direct access to repository sites holding resources of interest and (b) discuss the commitment to nomenclature standards among resources that remain a challenge in unifying mouse resource catalogs.

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