精神药物与耐药微生物的讨论。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2022-11-01 Epub Date: 2022-10-14 DOI:10.1089/dna.2022.0471

Lori Ellezian, Archana Jhawar, Yasuhiro Kyono, Stephanie A Flowers

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引用次数: 0

摘要

人们早就知道精神药物对几种微生物具有抗菌活性。尽管这一特性已被广泛研究，无论是单独使用还是与抗生素联合使用，以对抗具有抗菌素耐药性的细菌和真菌物种，但相对而言，很少有人关注它们导致抗菌素耐药性(AMR)出现的能力。我们最近报道了大肠杆菌在暴露于肠道相关浓度的抗精神病药物喹硫平后获得多药耐药。考虑到这些观察结果，本综述试图确定精神药物与微生物抗菌素耐药性之间的关系是否已在科学文献中定义。

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Psychotropic Drugs in the Discussion of Antimicrobial-Resistant Microorganisms.

Psychotropic drugs have long been known to possess antimicrobial activity against several groups of microorganisms. Although this property has been extensively studied both alone and when combined with antibiotics against antimicrobial-resistant bacterial and fungal species, relatively little attention has been given to their ability to contribute to the emergence of antimicrobial resistance (AMR). We have recently reported the acquisition of multidrug resistance in Escherichia coli after exposure to gut-relevant concentrations of the antipsychotic quetiapine. Considering these observations, this review attempts to establish if a relationship between psychotropics and AMR in microorganisms has been defined in the scientific literature.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.