{"title":"印度癌前病变和疾病的患病率:系统回顾和荟萃分析。","authors":"Abhishek Kumbhalwar, Sahana Hegde Shetiya, Pradnya Kakodkar, Vini Mehta, Ankita Mathur, Priyanka Porwal","doi":"10.5662/wjm.v12.i4.293","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Smoking and chewing tobacco are associated with numerous oral mucosal lesions and conditions, often leading to cancer progression.</p><p><strong>Aim: </strong>To investigate the prevalence of precancerous lesions and conditions among the Indian population.</p><p><strong>Methods: </strong>Systematic search was conducted for population or community-based observational epidemiological studies in PubMed, EMBASE, Web of Science, IndMED, Google Scholar, reports of the WHO South-East Asia Region, MOHFW India reports, Science Citation Index, WHO Index Medicus of the South-East Asian Region, <i>Reference Citation Analysis</i> (https://www.referencecitationanalysis.com/) and Open Grey from the earliest available up to 31<sup>st</sup> January 2022. The effect size was calculated for the prevalence of precancerous lesions and conditions.</p><p><strong>Results: </strong>One hundred sixty-two estimates from 130 studies yielded 52 high, 71 moderate, and seven low-quality studies from 823845. Point estimate based on cross-sectional studies for leukoplakia was 4.3% (95%CI: 4.0-4.6), oral submucous fibrosis was 2.7% (95%CI: 2.5-3.0), palatal lesions in reverse smokers and nicotine palatine were 5.8% (95%CI: 4.4-7.2), and Erythroplakia was 1.2% (95%CI: 0.7-1.7), and lichen planus was 1.1% (95%CI: 0.9-1.2). Amongst hospital-based studies, the pooled prevalence for Leukoplakia was 6.7% (95%CI: 6.0-7.3), oral submucous fibrosis was 4.5% (95%CI: 4.2-4.9), lichen planus was 7.5% (95%CI: 5.3-9.6), and erythroplakia was 2.5% (95%CI: 0.4-4.5), and palatal lesions in reverse smokers and nicotine palatini were 11.5% (95%CI: 8.0-15.0).</p><p><strong>Conclusion: </strong>Precancerous lesions and conditions are prevailing problems among the Indian population. It is mainly due to tobacco use, the smokeless form of tobacco. The meta-analysis indicates that hospital-based studies have a higher effect size of 6.7% than community-based studies. Patients who have already developed this condition may be advised to reduce their exposure to the risk factor to prevent the condition from progressing further.</p>","PeriodicalId":23729,"journal":{"name":"World journal of methodology","volume":"12 4","pages":"293-304"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/2c/WJM-12-293.PMC9350727.pdf","citationCount":"3","resultStr":"{\"title\":\"Prevalence of precancerous lesions and conditions in India: A systematic review and meta-analysis.\",\"authors\":\"Abhishek Kumbhalwar, Sahana Hegde Shetiya, Pradnya Kakodkar, Vini Mehta, Ankita Mathur, Priyanka Porwal\",\"doi\":\"10.5662/wjm.v12.i4.293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Smoking and chewing tobacco are associated with numerous oral mucosal lesions and conditions, often leading to cancer progression.</p><p><strong>Aim: </strong>To investigate the prevalence of precancerous lesions and conditions among the Indian population.</p><p><strong>Methods: </strong>Systematic search was conducted for population or community-based observational epidemiological studies in PubMed, EMBASE, Web of Science, IndMED, Google Scholar, reports of the WHO South-East Asia Region, MOHFW India reports, Science Citation Index, WHO Index Medicus of the South-East Asian Region, <i>Reference Citation Analysis</i> (https://www.referencecitationanalysis.com/) and Open Grey from the earliest available up to 31<sup>st</sup> January 2022. The effect size was calculated for the prevalence of precancerous lesions and conditions.</p><p><strong>Results: </strong>One hundred sixty-two estimates from 130 studies yielded 52 high, 71 moderate, and seven low-quality studies from 823845. Point estimate based on cross-sectional studies for leukoplakia was 4.3% (95%CI: 4.0-4.6), oral submucous fibrosis was 2.7% (95%CI: 2.5-3.0), palatal lesions in reverse smokers and nicotine palatine were 5.8% (95%CI: 4.4-7.2), and Erythroplakia was 1.2% (95%CI: 0.7-1.7), and lichen planus was 1.1% (95%CI: 0.9-1.2). Amongst hospital-based studies, the pooled prevalence for Leukoplakia was 6.7% (95%CI: 6.0-7.3), oral submucous fibrosis was 4.5% (95%CI: 4.2-4.9), lichen planus was 7.5% (95%CI: 5.3-9.6), and erythroplakia was 2.5% (95%CI: 0.4-4.5), and palatal lesions in reverse smokers and nicotine palatini were 11.5% (95%CI: 8.0-15.0).</p><p><strong>Conclusion: </strong>Precancerous lesions and conditions are prevailing problems among the Indian population. It is mainly due to tobacco use, the smokeless form of tobacco. The meta-analysis indicates that hospital-based studies have a higher effect size of 6.7% than community-based studies. 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引用次数: 3
摘要
背景:吸烟和咀嚼烟草与许多口腔粘膜病变和状况有关，经常导致癌症进展。目的:调查印度人群中癌前病变的患病率和状况。方法:系统检索PubMed、EMBASE、Web of Science、IndMED、Google Scholar、WHO东南亚地区报告、MOHFW印度报告、Science Citation Index、WHO Index Medicus of southeast Asian Region、Reference Citation Analysis (https://www.referencecitationanalysis.com/)和Open Grey中最早到2022年1月31日的人口或社区观察性流行病学研究。效应量是根据癌前病变和疾病的患病率计算的。结果:来自130项研究的162项估计从823845项研究中得出52项高质量研究，71项中等质量研究和7项低质量研究。基于横断面研究的点估计白斑为4.3% (95%CI: 4.0-4.6)，口腔黏膜下纤维化为2.7% (95%CI: 2.5-3.0)，反吸烟者和尼古丁腭病变为5.8% (95%CI: 4.4-7.2)，红斑为1.2% (95%CI: 0.7-1.7)，扁平苔藓为1.1% (95%CI: 0.9-1.2)。在以医院为基础的研究中，白斑的总患病率为6.7% (95%CI: 6.0-7.3)，口腔黏膜下纤维化为4.5% (95%CI: 4.2-4.9)，扁平苔藓为7.5% (95%CI: 5.3-9.6)，红斑病为2.5% (95%CI: 0.4-4.5)，而反吸烟者和尼古丁palatini的腭病变为11.5% (95%CI: 8.0-15.0)。结论:癌前病变和状况是印度人口中普遍存在的问题。这主要是由于烟草的使用，烟草的无烟形式。荟萃分析表明，以医院为基础的研究比以社区为基础的研究具有更高的效应量6.7%。可能建议已经出现这种情况的患者减少与危险因素的接触，以防止病情进一步发展。
Prevalence of precancerous lesions and conditions in India: A systematic review and meta-analysis.
Background: Smoking and chewing tobacco are associated with numerous oral mucosal lesions and conditions, often leading to cancer progression.
Aim: To investigate the prevalence of precancerous lesions and conditions among the Indian population.
Methods: Systematic search was conducted for population or community-based observational epidemiological studies in PubMed, EMBASE, Web of Science, IndMED, Google Scholar, reports of the WHO South-East Asia Region, MOHFW India reports, Science Citation Index, WHO Index Medicus of the South-East Asian Region, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and Open Grey from the earliest available up to 31st January 2022. The effect size was calculated for the prevalence of precancerous lesions and conditions.
Results: One hundred sixty-two estimates from 130 studies yielded 52 high, 71 moderate, and seven low-quality studies from 823845. Point estimate based on cross-sectional studies for leukoplakia was 4.3% (95%CI: 4.0-4.6), oral submucous fibrosis was 2.7% (95%CI: 2.5-3.0), palatal lesions in reverse smokers and nicotine palatine were 5.8% (95%CI: 4.4-7.2), and Erythroplakia was 1.2% (95%CI: 0.7-1.7), and lichen planus was 1.1% (95%CI: 0.9-1.2). Amongst hospital-based studies, the pooled prevalence for Leukoplakia was 6.7% (95%CI: 6.0-7.3), oral submucous fibrosis was 4.5% (95%CI: 4.2-4.9), lichen planus was 7.5% (95%CI: 5.3-9.6), and erythroplakia was 2.5% (95%CI: 0.4-4.5), and palatal lesions in reverse smokers and nicotine palatini were 11.5% (95%CI: 8.0-15.0).
Conclusion: Precancerous lesions and conditions are prevailing problems among the Indian population. It is mainly due to tobacco use, the smokeless form of tobacco. The meta-analysis indicates that hospital-based studies have a higher effect size of 6.7% than community-based studies. Patients who have already developed this condition may be advised to reduce their exposure to the risk factor to prevent the condition from progressing further.
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