Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang
{"title":"乍得患者乙型、戊型肝炎和登革热合并感染的血清学证据及其对血脂的影响","authors":"Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang","doi":"10.1155/2022/8373061","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Viral hepatitis is an endemic disease in Chad. However, few studies have documented coinfection cases and their impact on cardiovascular risk. This study is aimed at analyzing hepatitis B, E and dengue coinfection in a Chadian cohort and gauge its effect on lipidemia. <i>Patients and Methods</i>. From February to May 2021, 179 subjects were recruited from the Department of Gastroenterology and Internal Medicine of the National Reference University Hospital of N'Djamena and tested for viral hepatitis markers, including HBsAg and IgM/IgG anti-HEV and dengue infection, using the NS1/IgM/IgG kit. Serum transaminases and biomarkers of lipid profiles were assayed by colorimetry, and atherogenic indexes (AI) and coronary risk (CRI) were calculated.</p><p><strong>Results: </strong>Of the 179 subjects surveyed, 21.22% (38/179) tested positive for hepatitis B, 20% (27/135) for hepatitis E, and 1.66% (2/120) for dengue. However, most of the patients were found to be asymptomatic. Hepatitis B/E coinfection was more frequent in the study population (5.02%; 9/179) than dengue/hepatitis E coinfection (0.83%; 1/120; IgM). The prevalence of anti-HEV IgG antibodies was higher (18.52%) than that of IgM (1.48%). Furthermore, IgG antibodies levels in HEV-monoinfected subjects (11.05 ± 1.93 IU/mL, <i>N</i> = 15) were significantly higher (<i>p</i> < 0.05) than in coinfected patients (5.40 ± 1.31 IU/mL, <i>N</i> = 9). Subjects coinfected with HEV/HBV were associated with a significantly higher risk of lipodystrophy (coronary risk: 88.89% vs. 35.3%, relative risk (RR) = 2.55; <i>p</i> = 0.014), than HEV-monoinfected subjects, as evidenced by higher mean levels of triglycerides levels (219.88 ± 14.67 mg/dL vs. 191.82 ± 4.66 mg/dL, <i>p</i> < 0.05), more reduced HDL-C levels (9.05 ± 1.62 mg/dL vs. 18.93 ± 2.35 mg/dL, <i>p</i> < 0.05), increased mean CRI (13.81 ± 2.39 vs. 6.89 ± 1.93, <i>p</i> < 0.01), and AI (1.46 ± 0.10 vs. 1.05 ± 0.05, <i>p</i> < 0.01) values. However, they had normal transaminase values and a lower risk of developing a liver injury, although not significant (alanine aminotransferase: 0% vs. 29.4%, RR = 1, <i>p</i> = 0.128; aspartate aminotransferase: 0% vs. 5.88%, <i>p</i> = 1) than this group.</p><p><strong>Conclusion: </strong>HBV/HEV coinfection is frequent in the Chadian cohort and associated with an important risk of dyslipidemia. Further research is required to elucidate the mechanism of action.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":" ","pages":"8373061"},"PeriodicalIF":1.5000,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507763/pdf/","citationCount":"0","resultStr":"{\"title\":\"Serological Evidence of Hepatitis B and E and Dengue Coinfection in Chadian Patients and Impact on Lipidemia Profile.\",\"authors\":\"Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang\",\"doi\":\"10.1155/2022/8373061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Viral hepatitis is an endemic disease in Chad. However, few studies have documented coinfection cases and their impact on cardiovascular risk. This study is aimed at analyzing hepatitis B, E and dengue coinfection in a Chadian cohort and gauge its effect on lipidemia. <i>Patients and Methods</i>. From February to May 2021, 179 subjects were recruited from the Department of Gastroenterology and Internal Medicine of the National Reference University Hospital of N'Djamena and tested for viral hepatitis markers, including HBsAg and IgM/IgG anti-HEV and dengue infection, using the NS1/IgM/IgG kit. Serum transaminases and biomarkers of lipid profiles were assayed by colorimetry, and atherogenic indexes (AI) and coronary risk (CRI) were calculated.</p><p><strong>Results: </strong>Of the 179 subjects surveyed, 21.22% (38/179) tested positive for hepatitis B, 20% (27/135) for hepatitis E, and 1.66% (2/120) for dengue. However, most of the patients were found to be asymptomatic. Hepatitis B/E coinfection was more frequent in the study population (5.02%; 9/179) than dengue/hepatitis E coinfection (0.83%; 1/120; IgM). The prevalence of anti-HEV IgG antibodies was higher (18.52%) than that of IgM (1.48%). Furthermore, IgG antibodies levels in HEV-monoinfected subjects (11.05 ± 1.93 IU/mL, <i>N</i> = 15) were significantly higher (<i>p</i> < 0.05) than in coinfected patients (5.40 ± 1.31 IU/mL, <i>N</i> = 9). Subjects coinfected with HEV/HBV were associated with a significantly higher risk of lipodystrophy (coronary risk: 88.89% vs. 35.3%, relative risk (RR) = 2.55; <i>p</i> = 0.014), than HEV-monoinfected subjects, as evidenced by higher mean levels of triglycerides levels (219.88 ± 14.67 mg/dL vs. 191.82 ± 4.66 mg/dL, <i>p</i> < 0.05), more reduced HDL-C levels (9.05 ± 1.62 mg/dL vs. 18.93 ± 2.35 mg/dL, <i>p</i> < 0.05), increased mean CRI (13.81 ± 2.39 vs. 6.89 ± 1.93, <i>p</i> < 0.01), and AI (1.46 ± 0.10 vs. 1.05 ± 0.05, <i>p</i> < 0.01) values. However, they had normal transaminase values and a lower risk of developing a liver injury, although not significant (alanine aminotransferase: 0% vs. 29.4%, RR = 1, <i>p</i> = 0.128; aspartate aminotransferase: 0% vs. 5.88%, <i>p</i> = 1) than this group.</p><p><strong>Conclusion: </strong>HBV/HEV coinfection is frequent in the Chadian cohort and associated with an important risk of dyslipidemia. Further research is required to elucidate the mechanism of action.</p>\",\"PeriodicalId\":46297,\"journal\":{\"name\":\"International Journal of Hepatology\",\"volume\":\" \",\"pages\":\"8373061\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507763/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2022/8373061\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/8373061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:病毒性肝炎是乍得的一种地方病。然而,很少有研究记录了合并感染病例及其对心血管风险的影响。本研究旨在分析乍得队列中乙型肝炎、戊型肝炎和登革热合并感染,并评估其对血脂的影响。患者和方法。2021年2月至5月,从恩贾梅纳国立参考大学医院消化内科招募了179名受试者,使用NS1/IgM/IgG试剂盒检测病毒性肝炎标志物,包括HBsAg和IgM/IgG抗hev和登革热感染。采用比色法检测血清转氨酶和脂质谱生物标志物,计算动脉粥样硬化指数(AI)和冠状动脉风险(CRI)。结果:179名调查对象中,21.22%(38/179)乙型肝炎阳性,20%(27/135)戊型肝炎阳性,1.66%(2/120)登革热阳性。然而,大多数患者被发现无症状。乙肝/戊型肝炎合并感染在研究人群中更为常见(5.02%;9/179)高于登革热/戊型肝炎合并感染(0.83%;1/120;IgM)。抗hev IgG抗体阳性率(18.52%)高于IgM抗体阳性率(1.48%)。此外,单HEV感染者的IgG抗体水平(11.05±1.93 IU/mL, N = 15)显著高于合并感染患者(5.40±1.31 IU/mL, N = 9) (p < 0.05)。合并HEV/HBV感染者发生脂肪营养不良的风险显著高于合并感染患者(冠状动脉风险:88.89% vs. 35.3%,相对风险(RR) = 2.55;p = 0.014),表现为甘油三酯水平(219.88±14.67 mg/dL比191.82±4.66 mg/dL, p < 0.05)、HDL-C水平(9.05±1.62 mg/dL比18.93±2.35 mg/dL, p < 0.05)、平均CRI(13.81±2.39比6.89±1.93,p < 0.01)和AI(1.46±0.10比1.05±0.05,p < 0.01)升高。然而,他们的转氨酶值正常,发生肝损伤的风险较低,尽管不显著(丙氨酸转氨酶:0% vs. 29.4%, RR = 1, p = 0.128;谷草转氨酶:0% vs. 5.88%, p = 1)。结论:HBV/HEV合并感染在乍得队列中很常见,并与血脂异常的重要风险相关。其作用机制有待进一步研究。
Serological Evidence of Hepatitis B and E and Dengue Coinfection in Chadian Patients and Impact on Lipidemia Profile.
Objective: Viral hepatitis is an endemic disease in Chad. However, few studies have documented coinfection cases and their impact on cardiovascular risk. This study is aimed at analyzing hepatitis B, E and dengue coinfection in a Chadian cohort and gauge its effect on lipidemia. Patients and Methods. From February to May 2021, 179 subjects were recruited from the Department of Gastroenterology and Internal Medicine of the National Reference University Hospital of N'Djamena and tested for viral hepatitis markers, including HBsAg and IgM/IgG anti-HEV and dengue infection, using the NS1/IgM/IgG kit. Serum transaminases and biomarkers of lipid profiles were assayed by colorimetry, and atherogenic indexes (AI) and coronary risk (CRI) were calculated.
Results: Of the 179 subjects surveyed, 21.22% (38/179) tested positive for hepatitis B, 20% (27/135) for hepatitis E, and 1.66% (2/120) for dengue. However, most of the patients were found to be asymptomatic. Hepatitis B/E coinfection was more frequent in the study population (5.02%; 9/179) than dengue/hepatitis E coinfection (0.83%; 1/120; IgM). The prevalence of anti-HEV IgG antibodies was higher (18.52%) than that of IgM (1.48%). Furthermore, IgG antibodies levels in HEV-monoinfected subjects (11.05 ± 1.93 IU/mL, N = 15) were significantly higher (p < 0.05) than in coinfected patients (5.40 ± 1.31 IU/mL, N = 9). Subjects coinfected with HEV/HBV were associated with a significantly higher risk of lipodystrophy (coronary risk: 88.89% vs. 35.3%, relative risk (RR) = 2.55; p = 0.014), than HEV-monoinfected subjects, as evidenced by higher mean levels of triglycerides levels (219.88 ± 14.67 mg/dL vs. 191.82 ± 4.66 mg/dL, p < 0.05), more reduced HDL-C levels (9.05 ± 1.62 mg/dL vs. 18.93 ± 2.35 mg/dL, p < 0.05), increased mean CRI (13.81 ± 2.39 vs. 6.89 ± 1.93, p < 0.01), and AI (1.46 ± 0.10 vs. 1.05 ± 0.05, p < 0.01) values. However, they had normal transaminase values and a lower risk of developing a liver injury, although not significant (alanine aminotransferase: 0% vs. 29.4%, RR = 1, p = 0.128; aspartate aminotransferase: 0% vs. 5.88%, p = 1) than this group.
Conclusion: HBV/HEV coinfection is frequent in the Chadian cohort and associated with an important risk of dyslipidemia. Further research is required to elucidate the mechanism of action.
期刊介绍:
International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.