Alondra Frías, Ignacio Gacitúa, Rubén Torres, Luis Toro, Erico Segovia, Miriam Alvo, Jorge Rodríguez, Carlos Romero, María Eugenia Sanhueza
{"title":"[局部柠檬酸盐抗凝在持续肾替代治疗中的有效性]。","authors":"Alondra Frías, Ignacio Gacitúa, Rubén Torres, Luis Toro, Erico Segovia, Miriam Alvo, Jorge Rodríguez, Carlos Romero, María Eugenia Sanhueza","doi":"10.4067/S0034-98872022000300283","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anticoagulation in continuous renal replacement therapy (CRRT) is essential to counteract the coagulation cascade activation, induced by the dialysis circuit. Heparin is the most widely used anticoagulant, followed by regional citrate anticoagulation (RCA).</p><p><strong>Aim: </strong>To determine the effectiveness and safety of anticoagulant treatment with citrate in CRRT.</p><p><strong>Material and methods: </strong>Retrospective study of adults in CRRT hospitalized between the years 2014 and 2020 in critical units, who required change to RCA according to established protocols.</p><p><strong>Results: </strong>We studied 24 patients aged 63 ± 13 years (12 females). The reasons for admission were acute kidney injury (AKI) in 80% and stage 5 chronic kidney disease in 20%. The indication of RCA in 75% of patients was by coagulation of more than 3 circuits in 24 hours. The duration of the circuit in RCA was 18.5 ± 4.8 hours versus 11.9 ± 4.9 hours with heparin (p < 0.0001). There were 19 mild complications that did not affect the RCA.</p><p><strong>Conclusions: </strong>RCA is feasible to perform, it is a safe and efficient procedure if it is protocolized, allowing a longer duration of the dialysis circuit.</p>","PeriodicalId":21360,"journal":{"name":"Revista medica de Chile","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"[Effectiveness of regional citrate anticoagulation in continuous renal replacement therapy].\",\"authors\":\"Alondra Frías, Ignacio Gacitúa, Rubén Torres, Luis Toro, Erico Segovia, Miriam Alvo, Jorge Rodríguez, Carlos Romero, María Eugenia Sanhueza\",\"doi\":\"10.4067/S0034-98872022000300283\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Anticoagulation in continuous renal replacement therapy (CRRT) is essential to counteract the coagulation cascade activation, induced by the dialysis circuit. Heparin is the most widely used anticoagulant, followed by regional citrate anticoagulation (RCA).</p><p><strong>Aim: </strong>To determine the effectiveness and safety of anticoagulant treatment with citrate in CRRT.</p><p><strong>Material and methods: </strong>Retrospective study of adults in CRRT hospitalized between the years 2014 and 2020 in critical units, who required change to RCA according to established protocols.</p><p><strong>Results: </strong>We studied 24 patients aged 63 ± 13 years (12 females). The reasons for admission were acute kidney injury (AKI) in 80% and stage 5 chronic kidney disease in 20%. The indication of RCA in 75% of patients was by coagulation of more than 3 circuits in 24 hours. The duration of the circuit in RCA was 18.5 ± 4.8 hours versus 11.9 ± 4.9 hours with heparin (p < 0.0001). There were 19 mild complications that did not affect the RCA.</p><p><strong>Conclusions: </strong>RCA is feasible to perform, it is a safe and efficient procedure if it is protocolized, allowing a longer duration of the dialysis circuit.</p>\",\"PeriodicalId\":21360,\"journal\":{\"name\":\"Revista medica de Chile\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista medica de Chile\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4067/S0034-98872022000300283\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista medica de Chile","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4067/S0034-98872022000300283","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
[Effectiveness of regional citrate anticoagulation in continuous renal replacement therapy].
Background: Anticoagulation in continuous renal replacement therapy (CRRT) is essential to counteract the coagulation cascade activation, induced by the dialysis circuit. Heparin is the most widely used anticoagulant, followed by regional citrate anticoagulation (RCA).
Aim: To determine the effectiveness and safety of anticoagulant treatment with citrate in CRRT.
Material and methods: Retrospective study of adults in CRRT hospitalized between the years 2014 and 2020 in critical units, who required change to RCA according to established protocols.
Results: We studied 24 patients aged 63 ± 13 years (12 females). The reasons for admission were acute kidney injury (AKI) in 80% and stage 5 chronic kidney disease in 20%. The indication of RCA in 75% of patients was by coagulation of more than 3 circuits in 24 hours. The duration of the circuit in RCA was 18.5 ± 4.8 hours versus 11.9 ± 4.9 hours with heparin (p < 0.0001). There were 19 mild complications that did not affect the RCA.
Conclusions: RCA is feasible to perform, it is a safe and efficient procedure if it is protocolized, allowing a longer duration of the dialysis circuit.
期刊介绍：
La Revista Médica de Chile publica trabajos originales sobre temas de interés médico y de Ciencias Biomédicas, dando preferencia a los relacionados con la Medicina Interna y sus especialidades derivadas.
Publicada mensualmente, desde 1872, por la Sociedad Médica de Santiago.
La abreviatura de su título es Rev Med Chile, que debe ser usado en bibliografías, notas al pié de página, leyendas y referencias bibliográficas.
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