拉曼光谱技术用于阿尔茨海默病的调查和诊断。

Panagis Polykretis, Martina Banchelli, Cristiano D'Andrea, Marella de Angelis, Paolo Matteini
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引用次数: 5

摘要

阿尔茨海默病(AD)是最常见的神经退行性疾病,会导致记忆丧失、认知能力下降、身体功能障碍,最终导致死亡。越来越多的人患有阿尔茨海默病越来越敦促发展有效的早期诊断和监测技术。在这里,我们回顾了基于拉曼的技术领域的最新进展,这些技术显示出通过检测生物液体中的特定生物标志物来识别AD的巨大潜力,以及为参与疾病进展的关键分子提供基本见解或分析AD患者的组织学标本。这些技术包括自发和共振拉曼光谱,利用等离子体或光纤增强效应,如表面、尖端或光纤增强拉曼光谱,或涉及非线性技术,如相干拉曼散射。迄今为止所做的科学努力以及光学检测仪器(光谱仪、激光器、分析基质等)的快速技术进步和先进数据处理方法的普及表明,拉曼技术在阿尔茨海默病的临床前或临床检测方面发挥着主导作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Raman Spectroscopy Techniques for the Investigation and Diagnosis of Alzheimer's Disease.

Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in memory loss, cognitive decline, bodily function impairment, and finally death. The growing number of people suffering from AD increasingly urges the development of effective early diagnosis and monitoring techniques. Here, we review the most recent developments in the field of Raman-based techniques, which have shown a significant potential in identifying AD by detecting specific biomarkers in biological fluids, as well as in providing fundamental insights into key molecules involved in the disease progression or in the analysis of histological specimens of patients with AD. These techniques comprise spontaneous and resonant Raman spectroscopies, exploit plasmon- or fiber- enhanced effects, such as surface-, tip- or fiber- enhanced Raman spectroscopies, or involve non-linear techniques like coherent Raman scattering. The scientific efforts employed up to now as well as the rapid technological advancements in optical detection instruments (spectrometers, lasers, substrates for analysis, etc.) and the diffusion of advanced data processing methods suggest a leading role of Raman techniques in the perspective of a preclinical or clinical detection of AD.

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