Cho Rong Bae, Yoonhye Na, Minjae Cho, Yu Mi Hwang, Woo-Suk Tae, Sung-Bom Pyun
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Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) of both AF tracts were analyzed to evaluate the temporal changes in tract integrity and determine the correlation between changes (Δ; follow-up - initial) in DTI parameters and language scores.</p><p><strong>Results: </strong>At 6 months post-stroke, the mean FA decreased, and mean MD and RD increased in both hemispheres; however, compared with mean AD observed after 1 month, the mean observed at 6 months increased only in the left hemisphere (<i>P</i> < .05). ΔFA of the left AF and proportional change in the aphasia quotient showed a significant positive correlation (<i>r</i> = 0.365, <i>P</i> = .031). No correlation was found between changes in the right AF parameters and language score. The group with increased FA in the left AF showed more significant language improvement than the group with decreased FA.</p><p><strong>Conclusions: </strong>During the subacute stage, the integrity of AF decreased in both hemispheres in patients with aphasia, and the change in structural connectivity of the left AF was associated with language improvement.</p>","PeriodicalId":56104,"journal":{"name":"Neurorehabilitation and Neural Repair","volume":" ","pages":"633-644"},"PeriodicalIF":3.7000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Structural Changes in the Arcuate Fasciculus and Recovery of Post-stroke Aphasia: A 6-Month Follow-up Study using Diffusion Tensor Imaging.\",\"authors\":\"Cho Rong Bae, Yoonhye Na, Minjae Cho, Yu Mi Hwang, Woo-Suk Tae, Sung-Bom Pyun\",\"doi\":\"10.1177/15459683221121752\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Temporal changes in the structural connectivity of major language tracts after stroke and their contribution to aphasia recovery are unclear.</p><p><strong>Objective: </strong>To investigate longitudinal arcuate fasciculus (AF) integrity changes and their relationship with post-stroke aphasia recovery using diffusion tensor imaging (DTI).</p><p><strong>Methods: </strong>Thirty-five patients with aphasia due to first-ever left hemispheric stroke underwent the Korean version of the Western Aphasia Battery and DTI at 1- and 6-month post stroke onset. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) of both AF tracts were analyzed to evaluate the temporal changes in tract integrity and determine the correlation between changes (Δ; follow-up - initial) in DTI parameters and language scores.</p><p><strong>Results: </strong>At 6 months post-stroke, the mean FA decreased, and mean MD and RD increased in both hemispheres; however, compared with mean AD observed after 1 month, the mean observed at 6 months increased only in the left hemisphere (<i>P</i> < .05). ΔFA of the left AF and proportional change in the aphasia quotient showed a significant positive correlation (<i>r</i> = 0.365, <i>P</i> = .031). No correlation was found between changes in the right AF parameters and language score. 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引用次数: 4
摘要
背景:脑卒中后主要语言区域结构连接的时间变化及其对失语恢复的影响尚不清楚。目的:应用弥散张量成像(DTI)研究脑卒中后失语患者纵弓束(AF)完整性变化及其与失语恢复的关系。方法:35例首次左半球脑卒中失语患者在卒中后1个月和6个月分别进行了韩国版的西方失语电池和DTI。分析两AF束的分数各向异性(FA)、平均扩散率(MD)、径向扩散率(RD)和轴向扩散率(AD),以评估AF束完整性的时间变化并确定变化之间的相关性(Δ;后续-初始)在DTI参数和语言分数。结果:脑卒中后6个月,两脑半球平均FA下降,平均MD和RD增加;然而,与1个月后观察到的平均AD相比,6个月时观察到的平均AD仅在左半球增加(P r = 0.365, P = 0.031)。右心房颤动参数的变化与语言评分无相关性。左心房FA增加组比FA减少组表现出更显著的语言改善。结论:在亚急性期,失语症患者双脑心房颤动的完整性下降,左侧心房颤动结构连通性的改变与语言能力的提高有关。
Structural Changes in the Arcuate Fasciculus and Recovery of Post-stroke Aphasia: A 6-Month Follow-up Study using Diffusion Tensor Imaging.
Background: Temporal changes in the structural connectivity of major language tracts after stroke and their contribution to aphasia recovery are unclear.
Objective: To investigate longitudinal arcuate fasciculus (AF) integrity changes and their relationship with post-stroke aphasia recovery using diffusion tensor imaging (DTI).
Methods: Thirty-five patients with aphasia due to first-ever left hemispheric stroke underwent the Korean version of the Western Aphasia Battery and DTI at 1- and 6-month post stroke onset. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) of both AF tracts were analyzed to evaluate the temporal changes in tract integrity and determine the correlation between changes (Δ; follow-up - initial) in DTI parameters and language scores.
Results: At 6 months post-stroke, the mean FA decreased, and mean MD and RD increased in both hemispheres; however, compared with mean AD observed after 1 month, the mean observed at 6 months increased only in the left hemisphere (P < .05). ΔFA of the left AF and proportional change in the aphasia quotient showed a significant positive correlation (r = 0.365, P = .031). No correlation was found between changes in the right AF parameters and language score. The group with increased FA in the left AF showed more significant language improvement than the group with decreased FA.
Conclusions: During the subacute stage, the integrity of AF decreased in both hemispheres in patients with aphasia, and the change in structural connectivity of the left AF was associated with language improvement.
期刊介绍:
Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.