[应激反应和应激恢复在抑郁症发病机制中的作用:表观遗传机制的参与]。

IF 0.2 4区医学 Q4 NEUROSCIENCES

Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova Pub Date : 2015-01-01

G A Grigoryan, N V Gulyaeva

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引用次数: 0

摘要

本文分析了实验动物和人在不同生命阶段应激过程中应激反应和应激恢复在抑郁症发病机制中的表观遗传学研究数据。特定的染色质修饰，首先是组蛋白乙酰化和甲基化，控制着特定基因在不同大脑结构中的表达。讨论了与促抑郁或抗抑郁应激反应相关的特定基因的表观遗传调控(5HT转运体和受体、促肾上腺皮质激素释放激素、糖皮质激素及其受体、BDNF和其他神经营养因子)。

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[Stress reactivity and stress-resilience in the pathogenesis of depressive disorders: involvement of epigenetic mechanisms].

The data of epigenetic studies of stress reactivity and resilience in the pathogenesis of depression in experimental animals and humans subjected to stress at different periods of life are analyzed. Specific chromatin modifications, first of all histone acetylation and methylation, are controlling expression of definite genes in distinct brain structures. Epigenetic modulation of particular genes related to development of pro-depressive or antidepressive stress response are discussed (5HT transporter and receptors, corticotropin releasing hormone, glucocorticoid and their receptors, BDNF and other neurotrophic factors).

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