同步和异时性结直肠癌:不同的疾病实体还是不同的病程?

Hepato-gastroenterology Pub Date : 2015-03-01
Chih-Sheng Huang, Shung-Haur Yang, Chun-Chi Lin, Yuan-Tsiu Lan, Shin-Ching Chang, Huann-Sheng Wang, Wei-Shone Chen, Tzu-Chen Lin, Jen-Kou Lin, Jeng-Kai Jiang
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引用次数: 0

摘要

背景/目的:本研究旨在探讨同步和异时性结直肠癌(CRCs)的临床病理特征。方法:2001年1月1日至2010年12月31日,纳入5898例接受手术切除的crc患者。同步结直肠癌定义为原发肿瘤切除后6个月内存在一个以上的原发结直肠癌;而至少6个月后发生的CRC被视为异时性CRC。结果:5346例患者符合研究条件,分为孤立性、同步性和异时性CRC三组。同期结直肠癌的总患病率为2.2%,同期结直肠癌的10年累计发病率为0.84%。29例(64%)异时性癌在指标癌发生后3年内确诊,平均时间间隔为3.2年。男性性别和相关腺瘤的存在是同步性和异时性CRC的重要危险因素。同步和异时性CRC患者的临床病理特征相似,只是前者比后者年龄大3.7岁。三组患者的五年生存率无明显差异。结论:我们的研究表明同步性和异时性CRC可能代表了不同病程的类似疾病实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synchronous and metachronous colorectal cancers: distinct disease entities or different disease courses?

Background/aims: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).

Methodology: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.

Results: 5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.

Conclusions: Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.

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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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