胃癌不同pT分期淋巴结转移率与预后的关系。

Hepato-gastroenterology Pub Date : 2015-03-01
Xiaobao Li, Yongfeng Liu, Bo Cao, Bin Liu, Tiecheng Bai, Xiaoyong Li, Leyuan Mei, Xiangming Che
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引用次数: 0

摘要

背景/目的:本研究旨在探讨淋巴结转移率(MLR)在评价不同T期胃癌患者预后中的作用。方法:回顾性分析535例胃癌手术患者的临床资料。比较MLR与根据UICC/AJCC指南(第7版)确定的pN的预后价值,分析MLR的特点和优势。此外,我们还探讨了MLR在不同pT分期胃癌患者预后评价中的作用。结果:采用单因素Kaplan-Meier法进行生存分析,结果显示MLR与患者预后密切相关。Cox比例风险回归模型多因素分析显示,MLR是影响胃癌患者预后的主要独立危险因素。MLR预测胃癌患者术后5年内死亡的ROC曲线下面积与pN分期无关。MLR对pT2期、pT3期胃癌患者预后的预测效果显著(P < 0.05)。结论:MLR是影响胃癌预后的独立危险因素。MLR的预后能力与胃癌的pN期相当。因此,在评价胃癌患者,特别是pT2-pT3期胃癌患者的预后方面,它比pN更可靠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metastatic lymph node ratio and prognosis of gastric cancer at different pT stages.

Background/aims: This study aimed to investigate the role of metastatic lymph node ratio (MLR) in the evaluation of prognosis of patients with gastric cancer at different T stages.

Methodology: Clinical information was reviewed retrospectively in a total 535 patients who underwent surgery for gastric cancer. The prognostic value of MLR was compared with that of pN determined according to the UICC/AJCC guidelines (7th Edition), and the characteristics and advantages of MLR were analyzed. Moreover, the role of MLR in the evaluation of prognosis of patients with gastric cancer at different pT stages was investigated.

Results: Univariate Kaplan-Meier method was used for the analysis of survival, and the results showed that MLR was closely associated with the prognosis of these patients. Multivariate analysis with Cox proportional hazards regression model showed that MLR was a major independent risk factor in the prognosis of gastric cancer patients. The area under the ROC curve of MLR in predicting the death of gastric cancer patients within 5 years after surgery was not associated with pN stage. MLR was effective in predicting the prognosis of patients with stage pT2 or pT3 gastric cancer (P < 0.05).

Conclusions: MLR is an independent risk factor in the prognosis of gastric cancer. MLR has a prognostic ability comparable to that of pN stage in gastric cancer. Thus, it is more reliable than pN in the evaluation of prognosis of gastric cancer patients, especially those with stage pT2-pT3 gastric cancer.

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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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