酰腙卤化物与含氨基和硫酮基团的杂环反应的位点选择性导致具有潜在抗菌活性的融合杂环。

Bioorganicheskaia khimiia Pub Date : 2014-01-01
M E A Khalifa, M A Amin, M A N Mosselhi
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引用次数: 0

摘要

腙酰卤化物与6-(苄基氨基)-2-硫氧基-2,3-二氢-1H-嘧啶-4- 1和2,3-二氨基喹唑啉-4- 1位点选择性反应,得到3-取代-7-(苄基氨基)-1-苯基-[1,2,4]三唑啉[4,3-a]-嘧啶-5(1H)- 1,[1,2,4,5]四氮基[6,1-b]喹唑啉-6(4H)- 1和3-甲基-2-(4-取代-苯腙)-[1,2,4]三氮基[3,2-b]喹唑啉-10- 1,收率高。通过化学证据和IR、1H、13C NMR和MS谱对新合成化合物的结构进行了鉴定。此外,还对部分产品进行了抗细菌和真菌的筛选。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Site selectivity in reactions of hydrazonoyl halides with heterocycles containing amino and thione groups leading to fused heterocycles of potential antimicrobial activity.

Reaction of hydrazonoyl halides with 6-(benzylidenamino)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one and 2,3-diaminoquinazolin-4-one site-selectively afforded 3-substituted-7-(benzylidenamino)-1-phenyl-[1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones, [1,2,4,5]tetrazino[6,1-b]quinazolin-6(4H)-one, and 3-methyl-2-(4-substituted-phenylhydrazo)-[1,2,4]triazino[3,2-b]quinazolin-10-ones in good yields. The structures of the newly synthesized compounds were elucidated by chemical evidence and their IR, 1H, 13C NMR, and MS spectra. Furthermore, some of the products were screened against different strains of bacteria and fungi.

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