A A Shabalina, L A Liapina, D L Rochev, M V Kostyreva, M M Tanashian, Z A Suslina
{"title":"[调节含亮氨酸的甘脯氨酸在人血液中的体外降脂和纤溶作用]。","authors":"A A Shabalina, L A Liapina, D L Rochev, M V Kostyreva, M M Tanashian, Z A Suslina","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.</p>","PeriodicalId":77187,"journal":{"name":"Izvestiia Akademii nauk. Seriia biologicheskaia","volume":" ","pages":"85-9"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood].\",\"authors\":\"A A Shabalina, L A Liapina, D L Rochev, M V Kostyreva, M M Tanashian, Z A Suslina\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.</p>\",\"PeriodicalId\":77187,\"journal\":{\"name\":\"Izvestiia Akademii nauk. Seriia biologicheskaia\",\"volume\":\" \",\"pages\":\"85-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Izvestiia Akademii nauk. Seriia biologicheskaia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Izvestiia Akademii nauk. Seriia biologicheskaia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
体外研究了含亮氨酸的甘脯氨酸、Pro-Gly-Pro-Leu和亮氨酸- pro - gly - pro在脂质代谢紊乱患者血液中的降脂、纤溶和抗凝作用。发现了甘脯氨酸的降脂作用及其在人体血液中减少纤维蛋白聚合和增加纤维蛋白解聚的能力。通过脂质依赖性磷脂酶A2的调节，提出了多肽的脂溶作用的可能机制。
[In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood].
The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
