典型与非典型溶血性尿毒症综合征的病理生理及治疗

C. Picard , S. Burtey , C. Bornet , C. Curti , M. Montana , P. Vanelle
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引用次数: 47

摘要

溶血性尿毒症是一种罕见的疾病,经常导致儿童肾功能不全。最近的发现重新引起了人们对这种病理的兴趣。非典型溶血性尿毒综合征中新基因突变的发现以及表明典型溶血性尿毒综合征中补体途径参与的实验数据,为治疗开辟了新的前景。本文综述了典型和非典型溶血性尿毒症的病理生理学现状,并探讨了治疗的新观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathophysiology and treatment of typical and atypical hemolytic uremic syndrome

Hemolytic uremic syndrome is a rare disease, frequently responsible for renal insufficiency in children. Recent findings have led to renewed interest in this pathology. The discovery of new gene mutations in the atypical form of HUS and the experimental data suggesting the involvement of the complement pathway in the typical form, open new perspectives for treatment. This review summarizes the current state of knowledge on both typical and atypical hemolytic uremic syndrome pathophysiology and examines new perspectives for treatment.

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来源期刊
Pathologie-biologie
Pathologie-biologie 医学-病理学
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6-12 weeks
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