专家指定的职业多氯联苯暴露回顾性估计的有效性。

Annals of Occupational Hygiene Pub Date : 2015-06-01 Epub Date: 2015-03-03 DOI:10.1093/annhyg/mev001
Curt T DellaValle, Mark P Purdue, Mary H Ward, Sarah J Locke, Patricia A Stewart, Anneclaire J De Roos, Patricia Hartge, Nathanial Rothman, Melissa C Friesen
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引用次数: 5

摘要

病例对照研究中基于专家判断的回顾性暴露评估通常有效性未知,因为很难找到比较的金标准。我们调查了专家指定的回顾性职业多氯联苯(PCB)暴露估计与血清多氯联苯浓度之间的关系。对多中心国家癌症研究所非霍奇金淋巴瘤监测、流行病学和最终结果病例对照研究中的一部分病例(n = 94)和对照组(n = 96)进行了分析。根据受试者一生的工作经历,一名工业卫生学家为每个工作分配了接触多氯联苯的概率[
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure.

Assessment of retrospective exposures based on expert judgment in case-control studies is usually of unknown validity because of the difficulty in finding gold standards for comparison. We investigated the relationship between expert-assigned retrospective occupational polychlorinated biphenyl (PCB) exposure estimates and serum PCB concentrations. Analyses were conducted on a subset of cases (n = 94) and controls (n = 96) in the multi-center National Cancer Institute, Surveillance, Epidemiology, and End Results Case-Control Study of non-Hodgkin lymphoma. Based on the subjects' lifetime work histories, an industrial hygienist assigned each job a probability of PCB exposure [<5% (unexposed), 5-<50% (possibly exposed), ≥50% (probably exposed)]. Ordinary least squares regression was used to investigate associations between the probability rating and log-transformed lipid-adjusted serum levels of 14 PCB congeners and total PCBs (ΓPCBs). Compared to unexposed participants (n = 163), those with a probably exposed job (n = 7) had serum levels that were 87% higher for ΓPCBs (95% confidence interval: 1.33-2.62) and 38% of serum level variability was explained by the probability rating. Statistically significant associations between probability ratings and serum levels for 12 of 14 individual congeners were also observed. In summary, the observed contrast in PCB serum levels by probability rating provides support for the occupational PCB exposure assessment.

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