药物开发中的成像。

Q1 Pharmacology, Toxicology and Pharmaceutics

Progress in medicinal chemistry Pub Date : 2015-01-01 Epub Date: 2014-11-27 DOI:10.1016/bs.pmch.2014.10.002

James Nairne, Peter B Iveson, Andreas Meijer

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引用次数: 11

摘要

成像在疾病的诊断和对潜在疾病机制的理解的发展中发挥了重要作用，现在准备在新药物的开发中产生影响。本章讨论了使该领域为这一挑战做好准备的基础技术。特别是，磁共振成像和功能性磁共振成像的潜力概述，包括开发的新方法，以提供额外的信息，从扫描进行。随着放射化学的进步，各种新的放射性示踪剂得以合成，核医学领域的兴趣迅速增加。

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Imaging in drug development.

Imaging has played an important part in the diagnosis of disease and development of the understanding of the underlying disease mechanisms and is now poised to make an impact in the development of new pharmaceuticals. This chapter discusses the underlying technologies that make the field ready for this challenge. In particular, the potentials of magnetic resonance imaging and functional magnetic resonance imaging are outlined, including the new methods developed to provide additional information from the scans carried out. The field of nuclear medicine has seen a rapid increase in interest as advances in radiochemistry have enabled a wide range of new radiotracers to be synthesised.

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来源期刊

Progress in medicinal chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

15.60

自引率

0.00%

发文量

期刊介绍： This series has a long established reputation for excellent coverage of almost every facet of Medicinal Chemistry and is one of the most respected and instructive sources of information on the subject. The latest volume certifies to the continuing success of a unique series reflecting current progress in a broadly developing field of science.