聚乙二醇包覆枝状大分子的高分辨率原子力和扫描隧道显微镜成像。

Shawn Riechers, Qian Zhong, Nai-Ning Yin, Arpad Karsai, Sandro R P da Rocha, Gang-Yu Liu
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引用次数: 10

摘要

近年来,树状大分子作为药物递送载体显示出巨大的前景,因为它们可以合成具有设计尺寸和功能的最佳运输,靶向性和生物相容性。用于生物相容性的最著名的终端之一是聚乙二醇(PEG),其性能受其实际构象的影响。然而,单个PEG结合到软材料(如树状大分子)上的构象尚未被直接观察到。利用原子力显微镜(AFM)和扫描隧道显微镜(STM),本研究以迄今为止报道的最高分辨率表征了聚乙二醇化树状大分子所采用的结构。AFM成像使单个树状大分子的可视化,以及树状大分子核心和PEG壳的分化和表征。STM提供高分辨率PEG扩展的直接成像。总的来说,这项研究提供了对涂覆树状大分子结构的重要见解,这对于设计和开发更好的药物递送载体至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Resolution Imaging of Polyethylene Glycol Coated Dendrimers via Combined Atomic Force and Scanning Tunneling Microscopy.

Dendrimers have shown great promise as drug delivery vehicles in recent years because they can be synthesized with designed size and functionalities for optimal transportation, targeting, and biocompatibility. One of the most well-known termini used for biocompatibility is polyethylene glycol (PEG), whose performance is affected by its actual conformation. However, the conformation of individual PEG bound to soft materials such as dendrimers has not been directly observed. Using atomic force microscopy (AFM) and scanning tunneling microscopy (STM), this work characterizes the structure adopted by PEGylated dendrimers with the highest resolution reported to date. AFM imaging enables visualization of the individual dendrimers, as well as the differentiation and characterization of the dendrimer core and PEG shell. STM provides direct imaging of the PEG extensions with high-resolution. Collectively, this investigation provides important insight into the structure of coated dendrimers, which is crucial for the design and development of better drug delivery vehicles.

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来源期刊
Journal of drug delivery
Journal of drug delivery PHARMACOLOGY & PHARMACY-
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