抑郁症大鼠模型的海马形态:体育活动的影响。

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2015-01-30 eCollection Date: 2014-01-01 DOI:10.2174/1874440001509010001
Adam Sierakowiak, Anna Mattsson, Marta Gómez-Galán, Teresa Feminía, Lisette Graae, Sahar Nikkhou Aski, Peter Damberg, Mia Lindskog, Stefan Brené, Elin Åberg
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引用次数: 20

摘要

越来越多的体内和体外证据表明,患有抑郁症的人海马体积减少,脊柱密度改变。此外,在人类和动物模型中,体育活动具有抗抑郁作用,但在抑郁症模型中,体育活动对海马体积和脊柱数量的影响程度尚不清楚。本研究通过对啮齿动物抑郁遗传模型弗林德斯敏感系大鼠(Flinders Sensitive Line Rats, FSL)进行核磁共振成像(MRI)和离体高尔基染色,分析运动是否影响海马体积和脊柱密度。我们发现,在5周的时间里,以自主轮跑的形式进行的身体活动增加了海马体积。此外,跑步者在齿状回中也有更多的细棘。我们的研究结果表明,在FSL大鼠中,自主转轮运动可以抗抑郁,与海马体积和脊柱数量增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hippocampal morphology in a rat model of depression: the effects of physical activity.

Hippocampal morphology in a rat model of depression: the effects of physical activity.

Hippocampal morphology in a rat model of depression: the effects of physical activity.

Hippocampal morphology in a rat model of depression: the effects of physical activity.

Accumulating in vivo and ex vivo evidences show that humans suffering from depression have decreased hippocampal volume and altered spine density. Moreover, physical activity has an antidepressant effect in humans and in animal models, but to what extent physical activity can affect hippocampal volume and spine numbers in a model for depression is not known. In this study we analyzed whether physical activity affects hippocampal volume and spine density by analyzing a rodent genetic model of depression, Flinders Sensitive Line Rats (FSL), with Magnetic Resonance Imaging (MRI) and ex vivo Golgi staining. We found that physical activity in the form of voluntary wheel running during 5 weeks increased hippocampal volume. Moreover, runners also had larger numbers of thin spines in the dentate gyrus. Our findings support that voluntary wheel running, which is antidepressive in FSL rats, is associated with increased hippocampal volume and spine numbers.

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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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