首次心肌梗死后三个月内接受心脏手术的差异:瑞典国家队列研究。

Acute cardiac care Pub Date : 2015-03-01 Epub Date: 2015-03-25 DOI:10.3109/17482941.2015.1005101
Dong Yang, Stefan James, Ulf De Faire, Lars Alfredsson, Tomas Jernberg, Tahereh Moradi
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引用次数: 2

摘要

目的:探讨出生国家与首次心肌梗死(MI)后冠状动脉造影、经皮冠状动脉介入治疗(PCI)和冠状动脉旁路移植术(CABG)应用的关系。设计、环境和患者:2001年至2009年期间在瑞典冠状动脉护理部门收治的117,494名所有年龄段的心肌梗死患者在入院后随访三个月。主要观察指标:首次心肌梗死后接受冠状动脉造影、PCI或CABG治疗。结果:在研究期间,接受血管造影和PCI治疗的患者比例增加,而接受CABG治疗的患者比例也降低了。不论研究期间和移民背景如何,接受三种手术中的任何一种的妇女比例明显低于男性,延迟时间更长。总体而言,与瑞典出生的首次心肌梗死患者相比,外国出生的首次心肌梗死患者的血管造影术(HR = 1.30, 95% CI: 1.27-1.33)、PCI (HR = 1.27, 95% CI: 1.24-1.30)和CABG (HR = 1.21, 95% CI: 1.15-1.28)的发生率更高。在多变量模型中控制了潜在的混杂因素后,血管造影的总体差异消失,PCI和CABG的总体差异明显减小。然而,根据具体出生国家进行的多变量分层分析显示,乌干达(HR = 2.11, 95% CI: 1.00-4.43)和秘鲁(HR = 1.98, 95% CI: 1.07-3.68)出生的男性血管造影率较高,克罗地亚(HR = 0.71, 95% CI: 0.52-0.99)出生的男性血管造影率较低,泰国(HR = 0.49, 95% CI: 0.35-0.94)出生的女性血管造影率较低。PCI调整利率更高的女性出生在巴勒斯坦州(HR = 2.44, 95% CI: 1.15—-5.16)、伊拉克(HR = 1.34, 95% CI: 1.04—-1.74)和波兰(HR = 1.21, 95% CI: 1.02—-1.44)和CABG是率高于移民来自亚洲的部分地区,包括男性出生在斯里兰卡(HR = 3.19, 95% CI: 1.43—-7.12),印度(HR = 1.95, 95% CI: 1.21—-3.14)、越南(HR = 2.65, 95% CI: 1.32—-5.33),巴勒斯坦州(HR = 2.11, 95%置信区间CI: 1.06 - -4.24),和女人出生在叙利亚(HR = 2.36, 95%置信区间CI:1.25-4.45),伊拉克(HR = 1.74, 95% CI: 1.02-2.94)和土耳其(HR = 1.70, 95% CI: 1.03-2.79)。结论:观察到的移民,特别是在一些亚洲国家出生的移民的高CABG率不能用潜在的混杂因素来解释。这一人群中更严重的冠状动脉疾病可能解释了这一高发病率,但需要进一步研究。移民对冠状动脉疾病的早期认识和后续干预可以延长其寿命,降低医疗保健费用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differences in undergoing cardiac procedures within three months after first myocardial infarction by country of birth in women and men: a Swedish national cohort study.

Objective: To examine the relationship between country of birth and the utilization of coronary angiography, percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) after a first-time myocardial infarction (MI).

Design, setting and patients: 117,494 MI patients of all ages who were admitted to coronary care units between 2001 and 2009 in Sweden were followed-up for three months after admission.

Main outcome measures: Undergoing coronary angiography, PCI or CABG after first-time MI.

Results: proportion of patients undergoing angiography and PCI increased whereas proportion of patients undergoing CABG also delay time for all three procedures decreased over the study period. The proportion of women undergoing any of the three procedures was markedly lower and delay time longer than those of men regardless of study period and migration background. Overall foreign-born first MI patients had higher rate of angiography (HR = 1.30, 95% CI: 1.27-1.33), PCI (HR = 1.27, 95% CI: 1.24-1.30) and CABG (HR = 1.21, 95% CI: 1.15-1.28) compared with Sweden born first MI patients. After controlling for potential confounding factors in multivariable models, the overall differences vanished for angiography and reduced markedly for PCI and CABG. However, multivariable stratified analysis by specific country of birth yielded higher rate of angiography among men born in Uganda (HR = 2.11, 95% CI: 1.00-4.43) and Peru (HR = 1.98, 95% CI: 1.07-3.68) and lower rate among men born in Croatia (HR = 0.71, 95% CI: 0.52-0.99) and women born in Thailand (HR = 0.49, 95% CI: 0.35-0.94). PCI adjusted rates were higher among women born in Palestine state (HR = 2.44, 95% CI: 1.15-5.16), Iraq (HR = 1.34, 95% CI: 1.04-1.74) and Poland (HR = 1.21, 95% CI: 1.02-1.44) and rate of CABG was higher among immigrants from some parts of Asia, including men born in Sri Lanka (HR = 3.19, 95% CI: 1.43-7.12), India (HR = 1.95, 95% CI: 1.21-3.14), Vietnam (HR = 2.65, 95% CI: 1.32-5.33), Palestine State (HR = 2.11, 95% CI: 1.06-4.24), and women born in Syria (HR = 2.36, 95% CI: 1.25-4.45), Iraq (HR = 1.74, 95% CI: 1.02-2.94), and Turkey (HR = 1.70, 95% CI: 1.03-2.79).

Conclusions: The observed high rate of CABG for immigrants and particularly those born in some Asian countries was not explained by the potential confounding factors. A more severe coronary disease in this population might explain this high rate but needs further research. Awareness and subsequent intervention at earlier stage of coronary disease among immigrants could prolong their life and reduce the healthcare costs.

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